Ralph Meyer

Animal, Dairy and Veterinary Sciences

Pharmacology/Toxicology, Reproductive Biology, Epigenetics

Ralph G. Meyer

Contact Information

Office Location: AGRS 247
Phone: 435-797-1774
Email: ralph.meyer@usu.edu

Educational Background

PhD, Molecular Cell Biology, University of Kaiserslautern, 1998
Poly(ADP-ribose) metabolism in DNA repair and carcinogenesis
Molecular Cell Biology, (Botany, Biochemistry), University of Kaiserslautern, 1994
Methods for regeneration and transformation of the bean "Phaseolus vulgaris"


US citizen, PhD in Molecular Cell Biology (PhD, Univ. Kaiserslautern, DKFZ Heidelberg, Germany). Postdoctoral training, Molecular Toxicology (Tuebingen, Tucson). Faculty, SVM, University of Pennsylvania. Associate Dept. Head for SVM, USU.

Teaching Interests

VM7522-Fundamentals of Pharmacology (course director), VM7523 - Toxicology

Research Interests

Reproductive toxicology, developmental biology


Biology of Reproduction Top Reviewing Editor of 2017, 2018

Society for the Study of Reproduction

Edward A. Smuckler Memorial AACR Poster, 2004

American Association for Cancer Research, AACR

Travel Award, 2004

53rd Annual Fujihara Seminar, Tomakomai, Hokkaido, Japan.

NIH Ruth-Kirschstein-NRSA fellowship (T32, 2002-2004), 2002

National Institutes of Health

    Publications | Book Chapters

  • Meyer-Ficca, M., Meyer, R., (2019). Epigenetic Changes in the Paternal Germline: Transgenerational Epigenetics, 2nd Edition. Elsevier Academic Press
  • Meyer, R., Meyer-Ficca, M., Jacobson, E.L, Jacobson, M.K, (2004). Enzymes in poly(ADP-ribose) metabolism: Poly(ADP-ribosyl)ation. Landes Bioscience

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Journal Articles

Academic Journal

  • Cacciolatti, C., Meyer-Ficca, M., Southwood, L.L, Meyer, R., Bertolotti, L., Zarucco, L., (2019). In-vitro effects of poly(ADP-Ribose) polymerase inhibitors in an equine model of inflammation. American Journal of Veterinary Research , 80:7, 663-669. doi: DOI: 10.2460/ajvr.80.7.663
  • Palzer, L., Bader, J.J, Angel, F., Witzel, M., Blaser, S., McNeil, A., Wandersee, M.K, Leu, N.A, Lengner, C.J, Cho, C.E, Welch, K.D, Kirkland, J.B, Meyer, R., Meyer-Ficca, M., (2018). Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements for NAD+ Synthesis. Cell Reports, 25:5, 1359-1370. doi: doi: 10.1016/j.celrep.2018.09.091
  • Ketchum, C.C, Larsen, C.D, McNeil, A., Meyer-Ficca, M., Meyer, R., (2018). Early Histone H4 Acetylation during Chromatin Remodeling in Equine Spermatogenesis. , 98:1, 115-129. doi: https://doi.org/10.1093/biolre/iox159
  • Meyer, R., Ketchum, C.C, Meyer-Ficca, M., (2017). Heritable Sperm Chromatin Epigenetics: A Break to Remember. Biology of Reproduction, 97:6, 787-797. doi: https://doi.org/10.1093/biolre/iox137
  • Douglas, H.F, Southwood, L.L, Meyer-Ficca, M., Hart, S.K, Meyer, R., (2015). The activity and inhibition of poly(ADP-ribose) polymerase-1 in equine peripheral blood mononuclear cells in vitro. , 25:4, 528-37. doi: doi: 10.1111/vec.12316
  • Bryant, J.M, Donahue, G., Wang, X., Meyer-Ficca, M., Luense, L.J, Weller, A.H, Bartolomei, M.S, Blobel, G.A, Meyer, R., Garcia, B.A, Berger, S.L, (2015). Characterization of BRD4 during mammalian postmeiotic sperm development.. Molecular and cellular biology, 35:8, 1433-48.
  • Meyer-Ficca, M., Ihara, M., Bader, J.J, Leu, N.A, Beneke, S., Meyer, R., (2015). Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice.. Biology of reproduction, 92:3, 80.
  • Ihara, M., Meyer-Ficca, M., Leu, N.A, Rao, S., Li, F., Gregory, B.D, Zalenskaya, I.A, Schultz, R.M, Meyer, R., (2014). Paternal poly(ADP-ribose) metabolism modulates retention of inheritable sperm histones and early embryonic gene expression. PLOS Genetics, doi: 10.1371/journal.pgen.1004317
  • Bryant, J.M, Meyer-Ficca, M., Dang, V.M, Berger, S.L, Meyer, R., (2013). Separation of spermatogenic cell types using STA-PUT velocity sedimentation. J Vis Exp80
  • Meyer-Ficca, M., Lonchar, J.D, Ihara, M., Bader, J.J, Meyer, R., (2013). Alteration of poly(ADP-ribose) metabolism affects murine sperm nuclear architecture by impairing pericentric heterochromatin condensation. Chromosoma, 122:4, 319–335.
  • Meyer-Ficca, M., Meyer, R., (2011). Genetic approaches to targeting multiple PARP genes in a mammalian genome. Methods Mol. Biol., 780, 349–376.
  • Bermudez, Y., Benavente, C.A, Meyer, R., Coyle, W.R, Jacobson, M.K, Jacobson, E.L, (2011). Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation. PLoS ONE, 6:5, e20487.
  • Meyer-Ficca, M., Lonchar, J.D, Ihara, M., Meistrich, M.L, Austin, C.A, Meyer, R., (2011). Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis. Biol. Reprod., 84:5, 900–909.
  • Meyer-Ficca, M., Ihara, M., Lonchar, J.D, Meistrich, M.L, Austin, C.A, Min, W., Wang, Z.Q, Meyer, R., (2011). Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis. Biol. Reprod., 84:2, 218–228.
  • Whatcott, C.J, Meyer-Ficca, M., Meyer, R., Jacobson, M.K, (2009). A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence. Exp. Cell Res., 315:20, 3477–3485.
  • Meyer-Ficca, M., Lonchar, J., Credidio, C., Ihara, M., Li, Y., Wang, Z.Q, Meyer, R., (2009). Disruption of poly(ADP-ribose) homeostasis affects spermiogenesis and sperm chromatin integrity in mice. Biol. Reprod., 81:1, 46–55.
  • Meyer, R., Meyer-Ficca, M., Whatcott, C.J, Jacobson, E.L, Jacobson, M.K, (2007). Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity. Exp. Cell Res., 313:13, 2920–2936.
  • Gao, H., Coyle, D.L, Meyer-Ficca, M., Meyer, R., Jacobson, E.L, Wang, Z.Q, Jacobson, M.K, (2007). Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypomorphic mutant of poly(ADP-ribose) glycohydrolase. Exp. Cell Res., 313:5, 984–996.
  • Meyer-Ficca, M., Meyer, R., Jacobson, E.L, Jacobson, M.K, (2005). Poly(ADP-ribose) polymerases: managing genome stability. Int. J. Biochem. Cell Biol., 37:5, 920–926.
  • Meyer-Ficca, M., Scherthan, H., Burkle, A., Meyer, R., (2005). Poly(ADP-ribosyl)ation during chromatin remodeling steps in rat spermiogenesis. Chromosoma, 114:1, 67–74.
  • Meyer-Ficca, M., Meyer, R., Kaiser, H., Brack, A.R, Kandolf, R., Kupper, J.H, (2004). Comparative analysis of inducible expression systems in transient transfection studies. Anal. Biochem., 334:1, 9–19.
  • Cortes, U., Tong, W.M, Coyle, D.L, Meyer-Ficca, M., Meyer, R., Petrilli, V., Herceg, Z., Jacobson, E.L, Jacobson, M.K, Wang, Z.Q, (2004). Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Mol. Cell. Biol., 24:16, 7163–7178.
  • Meyer, R., Meyer-Ficca, M., Kaiser, H., Selinka, H.C, Kandolf, R., Kupper, J.H, (2004). Plasmid-based generation of recombinant coxsackievirus B3 particles carrying capsid gene replacement replicons. Virus Res., 104:1, 17–26.
  • Meyer-Ficca, M., Meyer, R., Coyle, D.L, Jacobson, E.L, Jacobson, M.K, (2004). Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments. Exp. Cell Res., 297:2, 521–532.
  • Grassi, G., Maccaroni, P., Meyer, R., Kaiser, H., D’Ambrosio, E., Pascale, E., Grassi, M., Kuhn, A., Di Nardo, P., Kandolf, R., Kupper, J.H, (2003). Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87. Carcinogenesis, 24:10, 1625–1635.
  • Meyer, R., Meyer-Ficca, M., Jacobson, E.L, Jacobson, M.K, (2003). Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23). Gene, 314, 181–190.
  • Brabeck, C., Pfeiffer, R., Leake, A., Beneke, S., Meyer, R., Burkle, A., (2003). L-selegiline potentiates the cellular poly(ADP-ribosyl)ation response to ionizing radiation. J. Pharmacol. Exp. Ther., 306:3, 973–979.
  • Burkle, A., Beneke, S., Brabeck, C., Leake, A., Meyer, R., Muiras, M.L, Pfeiffer, R., (2002). Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity. Exp. Gerontol., 37:10-11, 1203–1205.
  • Meyer, R., Kupper, J.H, Kandolf, R., Rodemann, H.P, (2002). Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro. Eur. J. Biochem., 269:1, 337–346.
  • Meyer, R., Muller, M., Beneke, S., Kupper, J.H, Burkle, A., (2000). Negative regulation of alkylation-induced sister-chromatid exchange by poly(ADP-ribose) polymerase-1 activity. Int. J. Cancer, 88:3, 351–355.
  • Beneke, S., Meyer, R., Burkle, A., (1997). Isolation of cDNA encoding full-length rat (Rattus norvegicus) poly (ADP-ribose) polymerase. Biochem. Mol. Biol. Int., 43:4, 755–761.
  • Van Gool, L., Meyer, R., Tobiasch, E., Cziepluch, C., Jauniaux, J.C, Mincheva, A., Lichter, P., Poirier, G.G, Burkle, A., Kupper, J.H, (1997). Overexpression of human poly(ADP-ribose) polymerase in transfected hamster cells leads to increased poly(ADP-ribosyl)ation and cellular sensitization to gamma irradiation. Eur. J. Biochem., 244:1, 15–20.
  • Meyer, R., Nagl, W., (1993). Endopolyploidy in the extraembryonic membranes of the snake, Elaphe guttata. Protoplasma172, 132-135. doi: 10.1007/BF01379370

Professional Journal

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Other

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.


VM 7522 - Fundamentals of Pharmacology, Fall 2020
VM 7523 - Veterinary Toxicology, Spring 2020
VM 7522 - Fundamentals of Pharmacology, Fall 2019
VM 7522 - Fundamentals of Pharmacology, Fall 2018
VM 7522 - Fundamentals of Pharmacology, Fall 2017
VM 7523 - Veterinary Toxicology, Spring 2017
VM 7522 - Fundamentals of Pharmacology, Fall 2016
VM 7523 - Veterinary Toxicology, Spring 2016
VM 7522 - Fundamentals of Pharmacology, Fall 2015
VM 7523 - Veterinary Toxicology, Spring 2015
VM 7522 - Fundamentals of Pharmacology, Fall 2014
VM 7523 - Veterinary Toxicology, Spring 2014
VM 7522 - Fundamentals of Pharmacology, Fall 2013

Graduate Students Mentored

Renata Hoskova, Animal, Dairy and Veterinary Sciences, July 2020
Chelsea Ketchum, Animal, Dairy and Veterinary Sciences, September 2015 - June 2017