Abby Benninghoff

Publications | Abstracts

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Book Chapters

• Walter, R.B, Tilton, S.C, Orner, G.O, Benninghoff, A., Bailey, G.S, Williams, D.E, (2008). Carcinogenesis models: focus on xiphophorus and rainbow trout: Oceans and Human Health. Risks and Remedies from the Seas.

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Journal Articles

Academic Journal

• Lazarus, L., Dederich, T.C, Anderson, S.N, Benninghoff, A., Berreau, L., (2022). Flavonol-Based Carbon Monoxide Delivery Molecule with Endoplasmic Reticulum, Mitochondria, And Lysosome Localization. ACS Medicinal Chemistry Letters, 13, 236-242. doi: 10.1021/acsmedchemlett.1c00595
• Rajasinghe, L.D, Benninghoff, A., Bates, M.A, Wierenga, K.A, Harkema, J.R, Pestka, J.J, (2021). Silica induction of diverse inflammatory proteome in lungs of lupus-prone mice quelled by dietary docosahexaenoic acid supplementation. Frontiers in Immunology
• Cuthbert, J.M, Russell, S.J, Polejaeva, I., Meng, Q., White, K.L, Benninghoff, A., (2021). Comparing mRNA and sncRNA profiles during the maternal-to-embryonic transition in bovine IVF and scNT embryos.. Biology of Reproduction, 105:6, 1401–1415. doi: 10.1093/biolre/ioab169
• Russell, S.J, Polejaeva, I.A, Meng, Q., White, K.L, Benninghoff, A.D, (2021). Dynamics of small non-coding RNAs in bovine scNT embryos through the maternal-to-embryonic transition. Biology of Reproduction, 105:4, 918-933. doi: 10.1093/biolre/ioab107
• Aardema, N.D, Rodriguez, D.M, Van Wettere, A., Benninghoff, A., Hintze, K.J, (2021). The Western Dietary Pattern Combined with Vancomycin-Mediated Changes to the Gut Microbiome Exacerbates Colitis Severity and Colon Tumorigenesis. Nutrients, 13:3, 881. doi: 10.3390/nu13030881
• Chauhan, S, Wagner, J.G, Benninghoff, A., Lewandowski, R.P, Favor, O.K, Wierenga, K.A, Gilley, K.N, Ross, E.A, Harakema, J.R, Pestka, J.J, (2021). Rapid Induction of Pulmonary Inflammation, Autoimmune Gene Expression, and Ectopic Lymphoid Neogenesis Following Acute Silica Exposure in Lupus-Prone Mice. Frontiers in Immunology, 12, 635138. doi: 10.3389/fimmu.2021.635138
• Popova, M., Soboleva, T., Benninghoff, A., Berreau, L., (2020). CO Sense and Release Flavonols: Progress toward the Development of an Analyte Replacement PhotoCORM for Use in Living Cells . ACS Omega, 17, 10021-10033.
• Lazarus, L.S, Benninghoff, A., Berreau, L., (2020). Development of Triggerable, Trackable and Targetable Carbon Monoxide Releasing Molecules. Acc. Chem. Res. , 53, 2273-2285.
• Rajasinghe, L.D, Li, Q.Z, Zhu, C., Yan, M., Chauhan, P.S, Wierenga, K.A, Bates, M.A, Harkema, J.R, Benninghoff, A., Pestka, J.J, (2020). Omega-3 fatty acid intake suppresses induction of diverse autoantibody repertoire by crystalline silica in lupus-prone mice. Autoimmunity, 53:7, 415-433. doi: 10.1080/08916934.2020.1801651
• Wierenga, K.A, Strakovsky, R.S, Benninghoff, A., Rajasinghe, L.D, Lock, A.L, Harkema, J.R, Pestka, J.J, (2020). Requisite omega-3 HUFA biomarker thresholds for preventing murine lupus flaring. Frontiers in Immunology, 11, 1796. doi: 10.3389/fimmu.2020.01796
• Gilley, K.N, Wierenga, K.A, Chauhuan, P.S, Wagner, J.G, Lewandowski, R.P, Ross, E.A, Lock, A.L, Harkema, J.R, Benninghoff, A., Pestka, J.J, (2020). Influence of total western diet on docosahexaenoic acid suppression of silica-triggered lupus flaring in NZBWF1 mice. Plos One, 15:5, e0233183. doi: 10.1371/journal.pone.0233183
• Benninghoff, A., Hintze, K.J, Monsanto, S., Rodriguez, D.M, Hunter, A., Phatak, S., Pestka, J.J, Van Wettere, A., Ward, R.E, (2020). Consumption of the total Western diet promotes colitis and inflammation-associated colorectal cancer in mice. Nutrients, 12:2, 544. doi: 10.3390/nu12020544
• Ward, R.E, Benninghoff, A., Hintze, K.J, (2020). Food matrix and the microbiome: considerations for pre-clinical chronic disease studies. Nutrition Research, 78, 1-10. doi: 10.1016/j.nutres.2020.02.012
• Benninghoff, A., Bates, M.A, Chauhan, P.S, Wierenga, K.A, Gilley, K.N, Holian, A., Harkema, J.R, Pestka, J.J, (2019). Docosahexaenoic acid consumption impedes early interferon- and chemokine-related gene expression while suppressing silica-triggered flaring of murine lupus. Frontiers in Immunology, 10, 2851. doi: 10.3389/fimmu.2019.02851
• Soboleva, T., Simons, C.R, Arcidiacono, A., Benninghoff, A., Berreau, L., (2019). Extra- vs. Intracellular Delivery of CO: Does it Matter for a Stable, Diffusible Gasotransmitter?. Journal of Medicinal Chemistry, 62, 9990-9994.
• Rodriguez, D., Benninghoff, A., Aardema, N., Phatak, S., Hintze, K.J, (2019). Basal diet determined long-term composition of the gut microbiome and mouse phenotype to a greater extent than fecal microbiome transfer from lean or obese human donors. Nutrients, 11:7, 1630. doi: doi.org/10.3390/nu11071630
• Bates, M.A, Benninghoff, A., Gilley, K.N, Holian, A., Harkema, J.R, Pestka, J.J, (2019). Mapping of dynamic transcriptome changes associated with silica-triggered autoimmune pathogenesis in the lupus-prone NZBWF1 mouse. Frontiers in Immunology, 10, 632. doi: 10.3389/fimmu.2019.00632
• Cuthbert, J., Russell, S., White, K.L, Benninghoff, A., (2019). The maternal-to-zygotic transition in bovine in vitro-fertilized embryos is associated with marked changes in small non-coding RNAs. Biology of Reproduction, 100:2, 331-350. doi: 10.1093/biolre/ioy190
• Bates, M.A, Akbari, P., Gilley, K.N, Jackson-Humbles, D.N, Wagner, J.G, Li, N., Kopec, A.K, Wierenga, K.M, Brandenberger, C., Holian, A., Benninghoff, A., Harkema, J.R, Pestka, J.J, (2018). Dietary Docosahexaenoic Acid Prevents Silica-Induced Development of Pulmonary Ectopic Germinal Centers and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse. Frontiers in Immunology, 9, article 2002. doi: 10.3389/fimmu.2018.02002
• Popova, M., Soboleva, T., Ayad, S., Benninghoff, A., Berreau, L., (2018). A Visible Light-activated Quinolone Carbon Monoxide-releasing Molecule: Prodrug and Albumin-assisted Delivery Enable Anti-cancer and Potent Anti-inflammatory Effects. Journal of the American Chemical Society, 140:30, 9721–9729. doi: 10.1021/jacs.8b06011
• Soboleva, T., Esquer, H.J, Anderson, S.N, Berreau, L., Benninghoff, A., (2018). Mitochondrial-Localized Versus Cytosolic Intracellular CO-Releasing Organic PhotoCORMs: Evaluation of CO Effects Using Bioenergetics. ACS Chemical Biology, doi: 10.1021/acschembio.8b00387
• Hintze, K.J, Benninghoff, A., Cho, C.E, Ward, R.E, (2018). Modeling the Western diet for pre-clinical investigations. Advances in Nutrition, 9:3, 263-271. doi: 10.1093/advances/nmy002
• Shi, B., Thomas, A., Benninghoff, A., Sessions, B., Meng, Q., Parasar, P., Rutigliano, H., White, K.L, Davies, C., (2018). Genetic and epigenetic regulation of major histocompatibility complex 1 class I gene expression in bovine trophoblast cells. American Journal of Reproductive Immunology, 79:e12779, 1-12. doi: 10.1111/aji.12779
• Soboleva, T., Benninghoff, A., Berreau, L., (2017). An H2S-sensing/CO-releasing Flavonol that Operates via Logic Gates. ChemPlusChem, 82, 1408-1412.
• Soboleva, T., Esquer, H., Benninghoff, A., Berreau, L., (2017). Sense and Release: A Thiol-responsive Flavonol-based PhotoCORM that Operates via a Multiple-input AND Logic Gate. Journal of the American Chemical Society, 139, 9435-9438. doi: 10.1021/jacs.7b04077
• Benninghoff, A., (2017). Data on the effect of in utero exposure to polycyclic aromatic hydrocarbons on genomewide patterns of DNA methylation in lung tissues. Data in Brief, 13, 498-513. doi: 10.1016/j.fct.2017.04.047
• Hintze, K.J, Benninghoff, A., Ward, R.E, (2017). Improving animal diets to increase relevance to human populations. Functional Foods in Health and Disease , 7:5, 329-337.
• Benninghoff, A., (2017). DNA methylation in lung tissues of mouse offspring exposed in utero to polycyclic aromatic hydrocarbons. Food and Chemical Toxicology, doi: 10.1016/j.fct.2017.04.047
• Benninghoff, A., (2017). Amplify your teaching impact: capitalizing on 1-on-1 instruction. Journal on Empowering Teaching Excellence, 1:1, 6-22.
• Ward, R.E, Benninghoff, A., Healy, B.J, Li, M., Vagu, B., Hintze, K.J, (2017). Consumption of the total Western diet differentially affects the response to green tea in rodent models of chronic disease compared to the AIN93G diet. Molecular Nutrition and Food Research, 61:4, 1600720The. doi: 10.1002/mnfr.201600720
• Monsanto, S.P, Hintze, K.J, Ward, R.E, Larson, D.P, Lefevre, M., Benninghoff, A., (2016). The new total Western diet for rodents does not induce an overweight phenotype or alter parameters of metabolic syndrome in mice. Nutrition Research, 36:9, 1031-1044. doi: 10.1016/j.nutres.2016.06.002
• Anderson, S.N, Richards, J.M, Esquer, H.J, Benninghoff, A., Arif, A.M, Berreau, L., (2015). A New Structurally-Tunable 3-Hydroxyflavone Motif for Visible Light-induced CO-releasing Molecules. ChemistryOpen, 4, 590-594.
• Benninghoff, A., Lefevre, M., Hintze, K.J, Ward, R.E, Broadbent, J.R, (2015). Fighting cancer with functional foods: new approaches to investigate the interactions of dietary bioactive chemicals and the gut microbiome. Journal of Developments in Sustainable Agriculture, 10:1, 34-54. doi: 10.11178/jdsa.10.34
• Davis, A.P, Benninghoff, A., Thomas, A., Sessions, B., White, K.L, (2015). DNA methylation of the LIN28 pseudogene family. BMC Genomics, 16, 287. doi: 10.1186/s12864-015-1487-3
• Saraf, S.L, Fish, T., Benninghoff, A., Buelt, A., Smith , R.C, Berreau, L., (2014). Photochemical Reactivity of RuII(n6-p-cymene) Flavonolate Complexes. Organometallics, 33, 6341-6351.
• Hintze, K.J, Lefevre, M., Ward, R.E, Benninghoff, A., Broadbent, J.R, Cox, J., (2014). Broad scope method for creating humanized animal models for animal health and disease research through antibiotic treatment and human fecal transfer. Gut Microbes, 5, 183-191. doi: 10.4161/gmic.28403
• Polejaeva, I., Broek, D., Walker, S., Zhou, W., Walton, M., Benninghoff, A., Faber, D., (2013). Longitudinal study of reproductive performance of female cattle produced by somatic cell nuclear transfer. PLoS One, 8:12, e84283. doi: 10.1371/journal.pone.0084283
• Benninghoff, A., Fish, T., Louderback, M., Williams, D., (2013). The role of estrogen receptor beta (ERb) in transplacental cancer prevention by indole-3-carbinol. Cancer Prevention Research.. Cancer Prevention Research, 6:4, 339-348. doi: 10.1158/1940-6207.CAPR-12-0311
• Shorey, L., Maughan, A., Wlliams, D., Dashwood, R., Ho, E., Benninghoff, A., (2012). 3,3’-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells. PLoS One, 7:4, e34975. doi: 10.1371/journal.pone.0034975
• Hintze, K.J, Benninghoff, A., Ward, R.E, (2012). Formulation of the Total Western Diet (TWD) as a basal diet for rodent cancer studies.. Journal of Agricultural and Food Chemistry, 60:27, 6736-6742. doi: 10.1021/jf204509a
• Benninghoff, A., Orner, G.A, Buchner, C., Hendricks, J.D, Duffy, A.M, Williams, D.E, (2012). Promotion of hepatocarcinogenesis by perfluoroalkyl acids in rainbow trout. Toxicological Sciences, 125:1, 69-78. doi: 10.1093/toxsci/kfr267
• Benninghoff, A., Bisson, W., Koch, D., Koluri, S.K, Williams, D.E, (2011). Estrogen-like activity of polyfluorinated chemicals in vivo and interaction with human and trout estrogen receptors in vitro. Toxicological Sciences, 120:1, 42-58. doi: 10.1093/toxsci/kfq379
• Salinas, K., Serrano, J., Higgins, L., Benninghoff, A., Williams, D., Walker, C., Hemmer, M., (2010). Identification of two isoforms of vitelline envelope protein in the plasma of rainbow trout exposed to 17β-estradiol. Molecular Reproduction and Development, 77:11, 963-970. doi: 10.1002/mrd.21244
• Williams, D.E, Willard, K.D, Orner, G.A, Hendricks, J.D, Pereira, C., Benninghoff, A., Bailey, G.S, (2009). Rainbow trout (Oncorhynchus mykiss) and ultra-low dose cancer studies. Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, 149:2, 175-81. doi: 10.1016/j.cbpc.2008.12.002
• Krueger, S.K, Henderson, M.C, Siddens, L.K, VanDyke, J.E, Benninghoff, A., Andrew, A.P, Furnes, B., Schlenk, D., Williams, D.E, (2009). Characterization of Sulfoxygenation and Structural Implications of Human Flavin-Containing Monooxygenase Isoform 2 (FMO2.1) Variants S195L and N413K. Drug Metabolism and Disposition, 37:8, 1785-1791. doi: 10.1124/dmd.109.027201
• Benninghoff, A., Williams, D.E, (2008). Identification of a transcriptional fingerprint of estrogen exposure in rainbow trout liver. Toxicological Sciences, 101:1, 65-80. doi: 10.1093/toxsci/kfm238
• Tilton, S.C, Orner, G.A, Benninghoff, A., Hendricks, J.D, Williams, D.E, (2008). Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout. Environmental Health Perspectives, 116:8, 1047-55.
• Mohamed, J.S, Benninghoff, A., Holt, G.J, Khan, I.A, (2007). Developmental expression of the G protein-coupled receptor 54 and three GnRH mRNAs in the teleost fish cobia. Journal of Molecular Endocrinology, 38:2, 235-44. doi: 10.1677/jme.1.02182
• Faulk, C.E, Benninghoff, A., Holt, G.J, (2007). Ontogeny of the gastrointestinal tract and selected digestive enzymes in cobia (Rachycentron canadum) larval development. Journal of Fish Biology, 70, 567-583. doi: 10.1111/j.1095-8649.2007.01330.x
• Benninghoff, A., (2007). Toxicoproteomics – the next step in the evolution of environmental biomarkers?. Toxicological Sciences , 95:1, 1-4. doi: 10.1093/toxsci/kfl157
• Benninghoff, A., Thomas, P., (2006). Gonadotropin regulation of testosterone synthesis by theca and granulosa cells of Atlantic croaker (Micropogonias undulatus): I. Role of CaMK in calcium-mediated steroidogenesis and interactions between calcium and adenylyl cyclase pathways. General and Comparative Endocrinology , 147:3, 276-287. doi: 10.1016/j.ygcen.2006.01.013
• Benninghoff, A., Thomas, P., (2006). Gonadotropin regulation of testosterone synthesis by theca and granulosa cells of Atlantic croaker (Micropogonias undulatus): II. Involvement of a mitogen-activated protein kinase pathway. General and Comparative Endocrinology , 147:3, 288-296. doi: 10.1016/j.ygcen.2006.01.014
• Thomas, P., Dressing, G., Pang, Y., Berg, H., Tubbs, C., Benninghoff, A., Doughty, D., (2006). Progestin, estrogen and androgen G-protein coupled receptors in fish gonads.. Steroids, 71:4, 310-316. doi: 10.1016/j.steroids.2005.09.015
• Benninghoff, A., Thomas, P., (2005). Involvement of calcium and calmodulin in the regulation of ovarian steroidogenesis in Atlantic croaker (Micropogonias undulatus) and modulation by Aroclor 1254. General and Comparative Endocrinology, 144:3, 211-223. doi: 10.1016/j.ygcen.2005.06.005
• Benninghoff, A., Thomas, P., (2003). Interactions of calcium and cyclic AMP signaling pathways regulating steroidogenesis in primary cultured theca and granulosa cells of Atlantic croaker. Fish Physiology and Biochemistry, 28:1-4, 327-328. doi: 10.1023/B:FISH.0000030572.66804.65

Professional Journal

• Hatton, T., Barnett, S., Benninghoff, A., Rashid, K., (2012). Productivity studies utilizing recombinant CHO cells in stirred-tank bioreactors: a comparative study between pitched-blade and backed-bed reactor systems. BioProcessing Journal, 11:2, 29-36.

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Other

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.