S. Clay Isom
Animal, Dairy & Vet Sciences
Developmental Genetics & Epigenetics
Expertise
Genomics and Epigenomics of Early Embryo Development // Program goals: To understand the molecular determinants of gamete and embryo quality; To understand the relationship between environmental factors (e.g., age, nutrition) and reproduction.
Biography
Born & raised in Lyman, Wyoming.
Teaching Interests
Reproductive physiology
Research Interests
epigenetics, embryo/environment interactions, preimplantation embryo development, oocyte quality
Awards
Teacher of the Year, 2016
ADVS Department
Teacher of the Year, 2016
CAAS
Teacher of the Year, 2015
ADVS Department
Graduate Research Mentor of the Year, 2014
ADVS
Graduate Research Mentor of the Year, 2014
CAAS
Dorris D. & Christine M. Brown Graduate Research Fellowship, 2003
University of Missouri–Columbia
USDA National Needs Travel Award, 2003
University of Missouri–Columbia
USDA/CSREES National Needs Graduate Student Fellowship, 2000
University of Missouri–Columbia
University Club Scholarship, 1997
Utah State University
University Club Scholarship, 1993
Utah State University
Publications | Abstracts
An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.
Publications | Fact Sheets
An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.
Publications | Journal Articles
Academic Journal
- Greenland, M., Waldron, B., Isom, S., Fonnesbeck, S., Peel, M., Rood, K., Thornton-Kurth, K., Miller, R.L, Hadfield, J., Henderson, B., Creech, J.E, (2023). Dry-matter intake and feed efficiency of heifers from four dairy breed-types grazing organic grass and grass-birdsfoot trefoil mixed pastures. Journal of Dairy Science, doi: https://doi.org/10.3168/jds.2022-22858
- Hadfield, J., Waldron, B.L, Isom, S., Creech, J.E, Rose, M.F, Long, J., Miller, R.L, Rood, K.A, Young, A., Stott, R.D, Sweat, A., Thornton-Kurth, K., (2021). The effects of grass and grass-legume pastures on organic dairy heifer development: Heifer growth and performance. Journal of Dairy Science, 104:10, 10863-10878. doi: https://doi.org/10.3168/jds.2020-19524
- Hadfield, J., Waldron, B.L, Isom, S., Feuz, R., Larsen, R., Creech, J.E, Rose, M.F, Long, J.N, Peel, M.D, Miller, R.L, Rood, K., Young, A., Stott, R.D, Sweat, A., Thornton, K.J, (2021). The effects of organic grass and grass-birdsfoot trefoil pastures on Jersey heifer development: Heifer growth, performance, and economic impact.. Journal of dairy science
- Rose, M.F, Waldron, B.L, Isom, S., Peel, M.D, Thornton, K.J, Miller, R.L, Rood, K., Hadfield, J., Henderson, B., Creech, J.E, (2021). The effects of organic grass and grass-birdsfoot trefoil pastures on Jersey heifer development: Herbage characteristics affecting intake.. Journal of Dairy Science
- Li, Q., Suasnavas, E., Heywood, S., Xiao, L., Zhou, A., Isom, S., (2015). Biochemical, biophysical and genetic changes of porcine trophoblast-derived stem-like cells during differentiation as evaluated using Raman microspectroscopy, Atomic force microscopy and quantitative polymerase chain reaction. genesis , The Journal of Genetics and Development , 53:12, 749-761. doi: doi: 10.1002/dvg.22907
- Li, Q., Suasnavas, E., Xiao, L., Heywood, S., Qi, X., Zhou, A., Isom, S., (2015). Label-Free and Non-Invasive Monitoring of Porcine Trophoblast Derived Cells: Differentiation in Serum and Serum-Free Media. Journal of Biophotonics, 8:8, 638-645. doi: doi:10.1002/jbio.201400062
- Cox, L., Vanderwall, D.K, Parkinson, K.C, Sweat, L., Isom, S., (2015). Expression profiles of select genes in cumulus-oocyte complexes from young and aged mares. Reproduction Fertility & Development, doi: doi: 10.1071/RD14446
- Sanz-Fernandez, M., Johnson, J., Abuajamieh, M., Stoakes, S., Seibert, J., Cox, L., Kahl, S., Elsasser, T., Ross, J., Isom, S., Rhoads, R., Baumgard, L., (2015). . Effects of heat stress on carbohydrate and lipid metabolism in growing pigs. Physiol Rep, 3:2, doi: doi: 10.14814/phy2.12315
- Suasnavas, E., Heywood, S., Ward, A., Cox, L., O'Grady, M., Zhao, Y., Isom, S., (2015). Isolation and characterization of trophoblast-derived stem-like cells from peri-implantation porcine embryos. Animal Reproduction Science, 154, 128-141. doi: doi: 10.1016/j.anireprosci.2015.01.012
- Saunders, G., Stevens, J.R, Isom, S., (2014). A shortcut for multiple testing on the directed acyclic graph of Gene Ontology. BMC Bioinformatics, 15:349, doi: DOI: 10.1186/s12859-014-0349-3
- Suasnavas, E., Heywood, S., Ward, A., Cox, L., O'Grady, M., Zhao, Y., Isom, S., Characterization of trophoblast-derived stem-like cells from peri-implantation porcine embryos.. Animal Reproduction Science
- Isom, S., Stevens, J.R, Li, R., Spollen, W., Cox, L., Spate, L., Murphy, C., Prather, R., (2013). Transcriptional profiling by RNA-Seq of peri-attachment porcine embryos generated using a variety of assisted reproductive technologies (ART). Physiol Genomics, 45:14, 577-589. doi: 10.1152/physiolgenomics.00094.2012
- Morrill, B.H, Cox, L., Ward, A., Heywood, S., Isom, S., Targeted DNA methylation analysis by high throughput sequencing in porcine peri-attachment embryos. Journal of Reproduction and Development
- Isom, S., Li, R., Whitworth, K.M, Prather, R.S, Timing of First Embryonic Cleavage Is a Positive Indicator of the In Vitro Developmental Potential of Porcine Embryos Derived From In Vitro Fertilization, Somatic Cell Nuclear Transfer and Parthenogenesis. Molecular Reproduction and Development, doi: 10.1002/mrd.22013
- Zhao, M., Whitworth, K., Lin, H., Zhang, X., Isom, S., Dobbs, K., Bauer, B., Prather, R., (2010). Porcine skin-derived progenitor (SKP) spheres and neurospheres: Distinct "stemness" identified by microarray analysis. Cell Reprogram, 12:3, 329-345.
- Isom, S., Prather, R., Rucker, E., (2009). Enhanced developmental potential of heat shocked porcine parthenogenetic embryos is related to accelerated mitogen-activated protein kinase dephosphorylation. Society of Reproductive and Fertility Supplement, 21:7, 892-900.
- Prather, R., Ross, J., Isom, S., Green, J., (2009). Transcriptional, post-transcriptional and epigenetic control of porcine oocyte maturation and embryogenesis. Society of Reproductive and Fertility Supplement, 66, 165-176.
- Isom, S., Lai, L., Prather, R., Rucker, E., (2009). Response of porcine cleavage-stage embryos to heat shock depends on timing of stressor application relative to oocyte activation. Molecular Reproduction & Development, 76:6, 548-554.
- Zhao, M., Isom, S., Lin, H., Hao, Y., Zhao, J., Whyte, J., Doggs, K., Zhang, Y., Prather, R., (2009). Tracing the stemness of porcine skin derived progenitors (pSKP) back to specific marker gene expression. Cloning Stem Cells, 11:1, 111-122.
- Li, R., Whitworth, K., Lai, L., Wax, D., Spate, L., Murphy, C., Rieke, A., Isom, S., Hao, Y., Zhong, Z., Katayama, M., Schatten, H., Prather, R., (2007). Concentration and composition of free amino acids and osmolalities of porcine oviductal and uterine fluid and their effects on development of porcine embryos. Molecular Reproduction & Development, 74, 1228-1235.
- Isom, S., Prather, P., Rucker III, E., (2007). Heat stress-induced apoptosis in porcine in vitro fertilized and parthenogenetic preimplantation-stage embryos. Molecular Reproduction & Development, 74, 574-581.
- Li, R., Murphy, C., Spate, L., Wax, D., Isom, S., Rieke, A., Walters, E., Samuel, M., Prather, R., (2007). Production of piglets after cryopreservation of embryos using a centrifugation-based method for delipation without micromanipulation. Molecular Reproduction & Development, 74, 1228-1235.
An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.
Publications | MultiMedia
Video
An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.
Publications | Other
Other
An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.