S. Clay Isom

Animal, Dairy & Vet Sciences

Developmental Genetics & Epigenetics


S. Clay Isom

Contact Information

Office Location: AGRS 243
Phone: (435) 797-8114
Email: clay.isom@usu.edu

Educational Background

PhD, Animal Sciences, University of Missouri, 2006
BS, Animal Science, Utah State University, 2000

Expertise

Genomics and Epigenomics of Early Embryo Development // Program goals: To understand the molecular determinants of gamete and embryo quality; To understand the relationship between environmental factors (e.g., age, nutrition) and reproduction.

Biography

Born & raised in Lyman, Wyoming.

Teaching Interests

Reproductive physiology

Research Interests

epigenetics, embryo/environment interactions, preimplantation embryo development, oocyte quality

Awards

Teacher of the Year, 2016

ADVS Department

Teacher of the Year, 2016

CAAS

Teacher of the Year, 2015

ADVS Department

Graduate Research Mentor of the Year, 2014

ADVS

Graduate Research Mentor of the Year, 2014

CAAS

Dorris D. & Christine M. Brown Graduate Research Fellowship, 2003

University of Missouri–Columbia

USDA National Needs Travel Award, 2003

University of Missouri–Columbia

USDA/CSREES National Needs Graduate Student Fellowship, 2000

University of Missouri–Columbia

University Club Scholarship, 1997

Utah State University

University Club Scholarship, 1993

Utah State University


Publications | Abstracts

    An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

    Publications | Fact Sheets

      An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

      Publications | Journal Articles

      Academic Journal

      • Greenland, M., Waldron, B., Isom, S., Fonnesbeck, S., Peel, M., Rood, K., Thornton-Kurth, K., Miller, R.L, Hadfield, J., Henderson, B., Creech, J.E, (2023). Dry-matter intake and feed efficiency of heifers from four dairy breed-types grazing organic grass and grass-birdsfoot trefoil mixed pastures. Journal of Dairy Science, doi: https://doi.org/10.3168/jds.2022-22858
      • Hadfield, J., Waldron, B.L, Isom, S., Creech, J.E, Rose, M.F, Long, J., Miller, R.L, Rood, K.A, Young, A., Stott, R.D, Sweat, A., Thornton-Kurth, K., (2021). The effects of grass and grass-legume pastures on organic dairy heifer development: Heifer growth and performance. Journal of Dairy Science, 104:10, 10863-10878. doi: https://doi.org/10.3168/jds.2020-19524
      • Hadfield, J., Waldron, B.L, Isom, S., Feuz, R., Larsen, R., Creech, J.E, Rose, M.F, Long, J.N, Peel, M.D, Miller, R.L, Rood, K., Young, A., Stott, R.D, Sweat, A., Thornton, K.J, (2021). The effects of organic grass and grass-birdsfoot trefoil pastures on Jersey heifer development: Heifer growth, performance, and economic impact.. Journal of dairy science
      • Rose, M.F, Waldron, B.L, Isom, S., Peel, M.D, Thornton, K.J, Miller, R.L, Rood, K., Hadfield, J., Henderson, B., Creech, J.E, (2021). The effects of organic grass and grass-birdsfoot trefoil pastures on Jersey heifer development: Herbage characteristics affecting intake.. Journal of Dairy Science
      • Li, Q., Suasnavas, E., Heywood, S., Xiao, L., Zhou, A., Isom, S., (2015). Biochemical, biophysical and genetic changes of porcine trophoblast-derived stem-like cells during differentiation as evaluated using Raman microspectroscopy, Atomic force microscopy and quantitative polymerase chain reaction. genesis , The Journal of Genetics and Development , 53:12, 749-761. doi: doi: 10.1002/dvg.22907
      • Li, Q., Suasnavas, E., Xiao, L., Heywood, S., Qi, X., Zhou, A., Isom, S., (2015). Label-Free and Non-Invasive Monitoring of Porcine Trophoblast Derived Cells: Differentiation in Serum and Serum-Free Media. Journal of Biophotonics, 8:8, 638-645. doi: doi:10.1002/jbio.201400062
      • Cox, L., Vanderwall, D.K, Parkinson, K.C, Sweat, L., Isom, S., (2015). Expression profiles of select genes in cumulus-oocyte complexes from young and aged mares. Reproduction Fertility & Development, doi: doi: 10.1071/RD14446
      • Sanz-Fernandez, M., Johnson, J., Abuajamieh, M., Stoakes, S., Seibert, J., Cox, L., Kahl, S., Elsasser, T., Ross, J., Isom, S., Rhoads, R., Baumgard, L., (2015). . Effects of heat stress on carbohydrate and lipid metabolism in growing pigs. Physiol Rep, 3:2, doi: doi: 10.14814/phy2.12315
      • Suasnavas, E., Heywood, S., Ward, A., Cox, L., O'Grady, M., Zhao, Y., Isom, S., (2015). Isolation and characterization of trophoblast-derived stem-like cells from peri-implantation porcine embryos. Animal Reproduction Science, 154, 128-141. doi: doi: 10.1016/j.anireprosci.2015.01.012
      • Saunders, G., Stevens, J.R, Isom, S., (2014). A shortcut for multiple testing on the directed acyclic graph of Gene Ontology. BMC Bioinformatics, 15:349, doi: DOI: 10.1186/s12859-014-0349-3
      • Suasnavas, E., Heywood, S., Ward, A., Cox, L., O'Grady, M., Zhao, Y., Isom, S., Characterization of trophoblast-derived stem-like cells from peri-implantation porcine embryos.. Animal Reproduction Science
      • Isom, S., Stevens, J.R, Li, R., Spollen, W., Cox, L., Spate, L., Murphy, C., Prather, R., (2013). Transcriptional profiling by RNA-Seq of peri-attachment porcine embryos generated using a variety of assisted reproductive technologies (ART). Physiol Genomics, 45:14, 577-589. doi: 10.1152/physiolgenomics.00094.2012
      • Morrill, B.H, Cox, L., Ward, A., Heywood, S., Isom, S., Targeted DNA methylation analysis by high throughput sequencing in porcine peri-attachment embryos. Journal of Reproduction and Development
      • Isom, S., Li, R., Whitworth, K.M, Prather, R.S, Timing of First Embryonic Cleavage Is a Positive Indicator of the In Vitro Developmental Potential of Porcine Embryos Derived From In Vitro Fertilization, Somatic Cell Nuclear Transfer and Parthenogenesis. Molecular Reproduction and Development, doi: 10.1002/mrd.22013
      • Zhao, M., Whitworth, K., Lin, H., Zhang, X., Isom, S., Dobbs, K., Bauer, B., Prather, R., (2010). Porcine skin-derived progenitor (SKP) spheres and neurospheres: Distinct "stemness" identified by microarray analysis. Cell Reprogram, 12:3, 329-345.
      • Isom, S., Prather, R., Rucker, E., (2009). Enhanced developmental potential of heat shocked porcine parthenogenetic embryos is related to accelerated mitogen-activated protein kinase dephosphorylation. Society of Reproductive and Fertility Supplement, 21:7, 892-900.
      • Prather, R., Ross, J., Isom, S., Green, J., (2009). Transcriptional, post-transcriptional and epigenetic control of porcine oocyte maturation and embryogenesis. Society of Reproductive and Fertility Supplement, 66, 165-176.
      • Isom, S., Lai, L., Prather, R., Rucker, E., (2009). Response of porcine cleavage-stage embryos to heat shock depends on timing of stressor application relative to oocyte activation. Molecular Reproduction & Development, 76:6, 548-554.
      • Zhao, M., Isom, S., Lin, H., Hao, Y., Zhao, J., Whyte, J., Doggs, K., Zhang, Y., Prather, R., (2009). Tracing the stemness of porcine skin derived progenitors (pSKP) back to specific marker gene expression. Cloning Stem Cells, 11:1, 111-122.
      • Li, R., Whitworth, K., Lai, L., Wax, D., Spate, L., Murphy, C., Rieke, A., Isom, S., Hao, Y., Zhong, Z., Katayama, M., Schatten, H., Prather, R., (2007). Concentration and composition of free amino acids and osmolalities of porcine oviductal and uterine fluid and their effects on development of porcine embryos. Molecular Reproduction & Development, 74, 1228-1235.
      • Isom, S., Prather, P., Rucker III, E., (2007). Heat stress-induced apoptosis in porcine in vitro fertilized and parthenogenetic preimplantation-stage embryos. Molecular Reproduction & Development, 74, 574-581.
      • Li, R., Murphy, C., Spate, L., Wax, D., Isom, S., Rieke, A., Walters, E., Samuel, M., Prather, R., (2007). Production of piglets after cryopreservation of embryos using a centrifugation-based method for delipation without micromanipulation. Molecular Reproduction & Development, 74, 1228-1235.

      An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

      Publications | MultiMedia

      Video

        An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

        Publications | Other

        Other

          An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

          Teaching

          ADVS 6700 - Epigenetics, Fall 2023
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2023
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2023
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2023
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2023
          ADVS 6800 - Graduate Student Seminar, Spring 2023
          ADVS 4920 - Undergraduate Seminar, Spring 2023
          , Fall 2022
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2022
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2022
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2022
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2022
          ADVS 6800 - Graduate Student Seminar, Spring 2022
          ADVS 4920 - Undergraduate Seminar, Spring 2022
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2021
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2021
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2021
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2021
          ADVS 6800 - Graduate Student Seminar, Spring 2021
          ADVS 4920 - Undergraduate Seminar, Spring 2021
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2020
          ADVS 4920 - Undergraduate Seminar, Fall 2020
          ADVS 6800 - Graduate Student Seminar, Spring 2020
          ADVS 4920 - Undergraduate Seminar, Spring 2020
          ADVS 6700 - Epigenetics, Fall 2019
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2019
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2019
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2019
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2019
          ADVS 4920 - Undergraduate Seminar, Fall 2019
          ADVS 6800 - Graduate Student Seminar, Spring 2019
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2018
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2018
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2018
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2018
          ADVS 6800 - Graduate Student Seminar, Spring 2018
          ADVS 6700 - Epigenetics, Fall 2017
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2017
          ADVS 6800 - Graduate Student Seminar, Spring 2017
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2016
          ADVS 6800 - Graduate Student Seminar, Spring 2016
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2015
          ADVS 6900 - Special Problems, Fall 2015
          ADVS 6800 - Graduate Student Seminar, Spring 2015
          ADVS 6200 - Physiology of Reproduction, Fall 2014
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2014
          ADVS 6800 - Graduate Student Seminar, Spring 2014
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2013
          ADVS 6200 - Physiology of Reproduction, Fall 2012
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2012
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2012
          ADVS 4200 - Physiology of Reproduction and Lactation, Fall 2012
          ADVS 4200 - Physiology of Reproduction and Lactation, Spring 2012
          ADVS 4200 - LABORATORY, Spring 2011
          ADVS 4200 - LABORATORY, Spring 2011
          ADVS 4200 - PHYL OF REPROD/LACTN (CI), Spring 2011
          ADVS 4200 - Physiology of Reprodution and Lactation, Spring 2011
          AG 422 - Physiology of Reproduction, 2007

          Graduate Students Mentored

          McKenna Perez, Animal, Dairy & Vet Sciences, August 2022
          Micah Forbush, Animal, Dairy & Vet Sciences, September 2021
          CONNOR WALDRON, Regional Campuses Distance Ed, June 2021
          Chase Goodey, Animal, Dairy & Vet Sciences, September 2020
          Madi Lindsey, Animal, Dairy & Vet Sciences, September 2019 - November 2021
          Sawyer Fonnesbeck, Animal, Dairy & Vet Sciences, June 2019 - August 2021
          Laura Moley, Animal, Dairy & Vet Sciences 2019
          Sameer Alhojaily, Animal, Dairy & Vet Sciences 2019
          Yuanfeng Zhao, Animal, Dairy & Vet Sciences 2019
          Lindsay Cox, Animal, Dairy & Vet Sciences, September 2011 - August 2016
          Edison Suasnavas, Animal, Dairy & Vet Sciences, September 2010 2012