Young-Min Lee PhD

Animal, Dairy, & Veterinary Sciences (ADVS)

Associate Professor


Young-Min Lee

Contact Information

Office Location: USTAR 650 Bldg, Room 205L
Phone: 435-797-9667
Email: youngmin.lee@usu.edu

Educational Background

PhD, Molecular Virology, (Molecular Microbiology and Immunology), Johns Hopkins University, 1998
Role of the human immunodeficiency virus type 1 matrix (MAp17) protein in viral morphogenesis in infected CD4+ T cells
BS, Biological Sciences, University of Minnesota, 1993
BS, Biology, Chung-Ang University, 1991
Teacher Certificate, Ministry of Education (South Korea), 1991

Biography

I received my first BS degree in Biology from Chung-Ang University (Seoul, South Korea) in 1991 and my second BS degree in Biological Sciences from the University of Minnesota (St. Paul, MN) in 1993. I then completed my PhD training in 1998 at Johns Hopkins University (Baltimore, MD). I did ~2 years of post-doctoral research at Washington University (St. Louis, MO). From 2000 to 2011, I was a faculty member of the Chungbuk National University Medical School (Cheongju, South Korea) and achieved the rank of full professor in 2011. In 2012, I joined the Utah State University as an Associate Professor of the Animal, Dairy and Veterinary Sciences department. I am currently directing a molecular virology laboratory, with a major focus on the molecular mechanisms of viral replication and pathogenesis of three clinically important human/animal pathogens, such as Japanese encephalitis virus (JEV, a flavivirus), Zika virus (ZIKV, a flavivirus), and porcine reproductive and respiratory syndrome virus (PRRSV, an arterivirus).

Research Interests

As a molecular virologist, the research in my laboratory focuses on elucidating the molecular mechanisms of viral replication and pathogenesis, a crucial step toward developing new antiviral therapeutic and preventive strategies against three plus-strand RNA viruses that are important for human/animal health: Japanese encephalitis virus (JEV), Zika virus (ZIKV), and porcine reproductive and respiratory syndrome virus (PRRSV). Although the three viruses are clinically important, the basis of their replication and pathogenesis remains largely unknown, mainly because these viruses contain a genome consisting of a single-strand, positive-sense RNA molecule that cannot be manipulated directly in vitro for functional studies of viral RNA sequences and gene products. During the past ~20 years, the research in my laboratory has made several major contributions to this field. One of the most significant accomplishments is the construction of full-length infectious cDNA molecular clones for each of these three RNA viruses that serve as a template for the genetic manipulation of the viral genome, allowing the production of molecularly defined mutant viruses for biological studies. By using our new infectious cDNA technology, combined with innovative molecular biology, cell biology, and biochemical techniques, our research will answer key questions about the viral life cycle and cellular and host responses to viral infections, enabling us to discover a novel target(s) for the development of antivirals and vaccines against JEV, ZIKV, and PRRSV, as well as closely related other pathogens.

Awards

Best Paper Award, 2020

Microbiological Society of Korea/Journal of Microbiology

CAAS College Researcher of the Year Award, 2018

Utah State University

ADVS Department Researcher of the Year Award , 2017

Utah State University

Gaeshin Academic Award, 2011

Chungbuk National University

Best Paper Award in Science and Technology, 2009

Korean Federation of Science and Technology Societies

Faculty Excellence Award, 2005

Chungbuk National University

Excellence in Scientific Research, 2004

Ministry of Health and Welfare (South Korea)

Katharine E. Welsh Fellowship, 1995

Johns Hopkins University


    Publications | Book Chapters

  • Yun, S., Lee, Y., (2020). Japanese encephalitis virus (Flaviviridae): Encyclopedia of Virology, 4th edition. Elsevier
  • Yun, S., Lee, Y., (2015). Japanese encephalitis: Antimicrobial Therapy and Vaccines (3rd ed). Antimicrobe.org
  • Lee, Y., (2013). Chapter 04: Diagnosis and Research Methods: Virology. Life Science
  • Lee, Y., (2013). Chapter 12: Flaviviruses: Virology. Life Science
  • Lee, Y., (2013). Chapter 17: Retroviruses: Virology. Life Science
  • Lee, Y., (2013). Chapter 22: HIV and AIDS : Virology. Life Science
  • Lee, Y., (2013). Chapter 04: Structure : Principles of Virology. World Science
  • Lee, Y., (2013). Chapter 06: Synthesis of RNA from RNA templates : Principles of Virology. World Science
  • Lee, Y., (2010). Chapter 04: Diagnosis and research methods: Virology. Life Science
  • Lee, Y., (2010). Chapter 12: Flavivirues: Virology. Life Science
  • Lee, Y., (2010). Chapter 18: Retroviruses: Virology. Life Science
  • Lee, Y., (2010). Chapter 24: Viral pathogenesis: Virology. Life Science
  • Lee, Y., (2010). Chapter 25: HIV and AIDS: Virology. Life Science
  • Lee, Y., (2009). Chapter 59: Flaviviridae: Medical Microbiology, 6e. Elsevier Korea
  • Lee, Y., (2008). Chapter 24: Enveloped RNA viruses: Nursing Microbiology, 1e. Elsevier Korea
  • Lee, Y., (2007). Chapter 61: Flaviviridae: Medical Microbiology, 5e. Elsevier Korea
  • Lee, Y., (2006). Chapter 11: Transformation: Fundamental Bacterial Genetics. World Science
  • Lee, Y., (2006). Chapter 12: Gene expression and regulation: Fundamental Bacterial Genetics. World Science
  • Yun, S., Lee, Y., (2006). Japanese encephalitis virus: Molecular biology and vaccine development: Molecular Biology of the Flavivirus. Horizon Bioscience (Horizon Scientific Press)
  • Lee, Y., (2005). Chapter 64: Flaviviridae: Medical Microbiology, 4e. Elsevier Singapore

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Journal Articles

Academic Journal

Professional Journal

    An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

    Publications | Other

    Magazine/Trade Publications

    An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

    Graduate Students Mentored

    Jiyoun Kim, Animal, Dairy & Vet Sciences, August 2020
    Joseph Goldhardt , Animal, Dairy & Vet Sciences, September 2017 - August 2019
    Jordan Frank, Animal, Dairy & Vet Sciences, September 2016 - August 2018
    Michael Woolley, Animal, Dairy & Vet Sciences, September 2016 - August 2018