Young-Min Lee PhD

Publications | Abstracts

• Kim, J., Song, B., Frank, J.C, Yun, S., Julander, J.G, Lee, Y., (2025). Comparison of three chimeric Zika vaccine prototypes developed on the genetic background of the clinically proven live-attenuated Japanese encephalitis vaccine SA14-14-2. Proceedings of the 2025 International Conference on Antiviral Research
• Lee, Y., Song, B., Yun, S., Goldhardt, J.L, Kim, J., (2024). Key virulence factors responsible for differences in pathogenicity between clinically proven live-attenuated Japanese encephalitis vaccine SA14-14-2 and its pre-attenuated highly virulent parent SA14. Proceedings of the 2024 Keystone Symposium (Positive Strand RNA Viruses)
• Yoo, D., Su, C., Kim , J., Tang, J., Hung, Y., Zuckermann, F.A, Husmann, R., Roady, P., Kim, J., Lee, Y., (2024). Immune antagonism-reprogrammed PRRS virus is clinically attenuated and devoid of overexpression of proinflammatory cytokines during coinfection with a secondary pathogen. Proceedings of the 2024 International Pig Veterinary Society Congress
• Kim, J., Davies, C.J, Gowen, B.B, Yoo, D., Lee, Y., (2024). A CRISPR screen identifies host factors involved in PRRSV replication in a pig macrophage cell line. Proceedings of the 2024 Conference of Research Workers in Animal Diseases

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Book Chapters

• Yun, S., Lee, Y., (2021). Japanese encephalitis virus (Flaviviridae): Encyclopedia of Virology, 4th edition. Academic Press
• Yun, S., Lee, Y., (2015). Japanese encephalitis: Antimicrobial Therapy and Vaccines (3rd ed). Antimicrobe.org
• Lee, Y., (2013). Chapter 04: Diagnosis and Research Methods: Virology. Life Science
• Lee, Y., (2013). Chapter 12: Flaviviruses: Virology. Life Science
• Lee, Y., (2013). Chapter 17: Retroviruses: Virology. Life Science
• Lee, Y., (2013). Chapter 22: HIV and AIDS : Virology. Life Science
• Lee, Y., (2013). Chapter 04: Structure : Principles of Virology. World Science
• Lee, Y., (2013). Chapter 06: Synthesis of RNA from RNA templates : Principles of Virology. World Science
• Lee, Y., (2010). Chapter 04: Diagnosis and research methods: Virology. Life Science
• Lee, Y., (2010). Chapter 12: Flavivirues: Virology. Life Science
• Lee, Y., (2010). Chapter 18: Retroviruses: Virology. Life Science
• Lee, Y., (2010). Chapter 24: Viral pathogenesis: Virology. Life Science
• Lee, Y., (2010). Chapter 25: HIV and AIDS: Virology. Life Science
• Lee, Y., (2009). Chapter 59: Flaviviridae: Medical Microbiology, 6e. Elsevier Korea
• Lee, Y., (2008). Chapter 24: Enveloped RNA viruses: Nursing Microbiology, 1e. Elsevier Korea
• Lee, Y., (2007). Chapter 61: Flaviviridae: Medical Microbiology, 5e. Elsevier Korea
• Lee, Y., (2006). Chapter 11: Transformation: Fundamental Bacterial Genetics. World Science
• Lee, Y., (2006). Chapter 12: Gene expression and regulation: Fundamental Bacterial Genetics. World Science
• Yun, S., Lee, Y., (2006). Japanese encephalitis virus: Molecular biology and vaccine development: Molecular Biology of the Flavivirus. Horizon Bioscience (Horizon Scientific Press)
• Lee, Y., (2005). Chapter 64: Flaviviridae: Medical Microbiology, 4e. Elsevier Singapore

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Journal Articles

Academic Journal

• Song, B., Yun, S., Goldhardt , J.L, Kim, J., Lee, Y., Key virulence factors responsible for differences in pathogenicity between clinically proven live-attenuated Japanese encephalitis vaccine SA14-14-2 and its pre-attenuated highly virulent parent SA14. PLOS Pathogens (PLOS Pathog)
• Song, B., Frank, J.C, Yun, S., Julander, J.G, Mason, J.B, Polejaeva, I.A, Davies, C.J, White, K.L, Dai, X., Lee, Y., (2024). Comparison of three chimeric Zika vaccine prototypes developed on the genetic background of the clinically proven live-attenuated Japanese encephalitis vaccine SA14-14-2. International Journal of Molecular Sciences (Int J Mol Sci), 26:1, 195.
• Su, C., Kim, J., Tang, J., Hung, Y., Zuckermann, F.A, Husmann, R., Roady, P., Kim, J., Lee, Y., Yoo, D., (2024). A clinically attenuated double-mutant of porcine reproductive and respiratory syndrome virus-2 that does not prompt overexpression of proinflammatory cytokines during co-infection with a secondary pathogen. PLOS Pathogens (PLOS Pathog), 20:3, e1012128.
• Frank, J.C, Song, B., Lee, Y., (2023). Mice as an animal model for Japanese encephalitis virus research: Mouse susceptibility, infection route, and viral pathogenesis. Pathogens, 12:5, 715.
• Yun, S., Song, B., Woolley, M.E, Frank, J.C, Julander, J., Lee, Y., (2020). Development, Characterization, and Application of Two Reporter-Expressing Recombinant Zika Viruses. Viruses, 12:5, E572.
• Hickerson, B.T, Westover, J.B, Wang, Z., Lee, Y., Gowen, B.B, (2019). Guinea pig transferrin receptor 1 mediates cellular entry of Junin virus and other pathogenic New World arenaviruses. Journal of Virology (J Virol), 94:4, e01278-19. doi: 10.1128/JVI.01278-19
• Yang, S., Sathish, A., Eun, J., Lee, Y., Fellner, V., Sims, R.C, (2019). In vitro ruminal fermentation characteristics of algal protein precipitate supplemented in lactation dairy diets in continuous cultures. International Journal of Innovative Research in Science, Engineering and Technology, 8:9, 9207-9218.
• Yun, S., Lee, Y., (2018). Early events in Japanese encephalitis virus infection: viral entry. Pathogens, 7:3, E68. doi: 10.3390/pathogens7030068
• Yun, S., Song, B., Frank, J.C, Julander, J.G, Olsen, A.L, Polejaeva, I.A, Davies, C.J, White, K.L, Lee, Y., (2018). Functional genomics and immunologic tools: the impact of viral and host genetic variations on the outcome of Zika virus infection. Viruses, 10:8, E422. doi: 10.3390/v10080422
• Song, B., Yun, S., Woolley, M., Lee, Y., (2017). Zika virus: history, epidemiology, transmission, and clinical presentation. Journal of Neuroimmunology (J Neuroimmunol), 308, 50-64. doi: 10.1016/j.jneuroim.2017.03.001
• Yun, S., Lee, Y., (2017). Zika virus: an emerging flavivirus. Journal of Microbiology (J Microbiol), 55:3, 204-219.
• Julander, J.G, Siddharthan, V., Evans, J., Taylor, R., Tolbert, K., Apuli, C., Stewart, J., Collins, P., Gebre, M., Neilson, S., Van Wettere, A., Lee, Y., Sheridan, W.P, Morrey, J.D, Babu, Y., (2017). Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model. Antiviral Research (Antiviral Res), 137, 14-22. doi: 10.1016/j.antiviral.2016.11.003
• Yun, S., Song, B., Polejaeva, I.A, Davies, C.J, White, K.L, Lee, Y., (2016). Comparison of the live-attenuated Japanese encephalitis vaccine SA14-14-2 strain with its pre-attenuated virulent parent SA14 strain: similarities and differences in vitro and in vivo. Journal of General Virology (J Gen Virol), 97:10, 2575-2591. doi: 10.1099/jgv.0.000574
• Yun, S., Song, B., Frank, J.C, Julander, J.G, Polejaeva, I.A, Davies, C.J, White, K.L, Lee, Y., (2016). Complete genome sequences of three historically important, spatiotemporally distinct, and genetically divergent strains of Zika virus: MR-766, P6-740, and PRVABC-59. Genome Announcements (Genome Announc), 4:4, e00800-16. doi: 10.1128/genomeA.00800-16
• Yun, S., Song, B., Frank, J.C, Julander, J.G, Polejaeva, I.A, Davies, C.J, White, K.L, Lee, Y., (2016). Complete genome sequences of three historically important, spatiotemporally distinct, and genetically divergent strains of Zika virus: MR-766, P6-740, and PRVABC-59. Genome Announcements (Genome Announc), 4:4, e00800-16. doi: 10.1128/genomeA.00800-16
• Yun, S., Song , B., Lee, Y., (2016). SA14-14-2Rep: a replicon vector derived from the live-attenuated Japanese encephalitis vaccine SA14-14-2 virus for human and veterinary medicine. Pediatric Infectious Diseases: Open Access, 1:1, e4.
• Yun, S., Song, B., Kim, J., Lee, Y., (2015). Bacterial artificial chromosomes: a functional genomics tool for the study of positive-strand RNA viruses. Journal of Visualized Experiments (J Vis Exp), 106, e53164. doi: 10.3791/53164
• Kim, J., Kim, J., Song, B., Yun, S., Yun, G., Byun, S., Lee, Y., (2015). Profiling of viral proteins expressed from the genomic RNA of Japanese encephalitis virus using a panel of 15 region-specific polyclonal rabbit antisera: implications for viral gene expression. PLoS ONE (PLoS ONE), 10:4, e0124318. doi: 10.1371/journal.pone.0124318
• Yun, S., Song, B., Kim, J., Yun, G., Lee, E., Li, L., Kuhn, R., Rossmann, M., Morrey, J., Lee, Y., (2015). A molecularly cloned, live-attenuated Japanese encephalitis vaccine SA14-14-2 virus. World Biomedical Frontiers, 1, 1-4.
• Yun, S., Song, B., Kim, J., Yun, G., Lee, E., Li, L., Kuhn, R.J, Rossmann, M.G, Morrey, J.D, Lee, Y., (2014). A molecularly cloned, live-attenuated Japanese encephalitis vaccine SA14-14-2 virus: A conserved single amino acid in the ij hairpin of the viral E glycoprotein determines neurovirulence in mice. PLOS Pathogens (PLOS Pathog), 10:7, e1004290. doi: doi: 10.1371/journal.ppat.1004290
• Yun, S., Lee, Y., (2014). Japanese encephalitis: the virus and vaccines. Human Vaccines and Immunotherapeutics (Hum Vaccin Immunother), 10:2, 263-279. doi: http://dx.doi.org/10.4161/hv.26902
• Yun, S., Lee, Y., (2013). Overview: replication of porcine reproductive and respiratory syndrome virus. Journal of Microbiology (J Microbiol), 51:6, 711–723. doi: 10.1007/s12275-013-3431-z
• Na, G., Wolfe, A., Ko, C., Youn, H., Lee, Y., Byun, S., Jeon, I., Koo, Y., (2013). A low-copy-number plasmid for retrieval of toxic genes from BACs and generation of conditional targeting constructs. Molecular Biotechnology (Mol Biotechnol), 54:2, 504-514. doi: 10.1007/s12033-012-9591-y
• Song, B., Yun, G., Kim, J., Yun, S., Lee, Y., (2012). Biological and genetic properties of SA14-14-2, a live-attenuated Japanese encephalitis vaccine that is currently available for humans. Journal of Microbiology (J Microbiol), 50:4, 698-706. doi: 10.1007/s12275-012-2336-6
• Lee, T., Song, B., Yun, S., Woo, H., Lee, Y., Diamond, M.S, Chung, K., (2012). A cross-protective mAb recognizes a novel epitope within the flavivirus NS1 protein. Journal of General Virology (J Gen Virol), 93:1, 20-26. doi: 10.1099/vir.0.036640-0
• Choi, B.K, Kim, Y.H, Choi, J.H, Kim, C.H, Kim, K., Sung, Y., Lee, Y., Moffett, J.R, Kwon, B.S, (2011). Unified immune modulation by 4-1BB triggering leads to diverse effects on disease progression in vivo. Cytokine (Cytokine), 55:3, 420-428. doi: 10.1016/j.cyto.2011.05.015
• Song, B., Kim, J., Kim, J., Jang, H., Yun, G., Choi, E., Song, J., Yun, S., Lee, Y., (2011). Packaging of porcine reproductive and respiratory syndrome virus replicon RNA by a stable cell line expressing its nucleocapsid protein. Journal of Microbiology (J Microbiol), 49:3, 516-523. doi: 10.1007/s12275-011-1280-1
• Park, J., Lee, S., Lee, Y., Jheong, W., Ryu, S., Paik, S., (2011). Full sequence analysis and characterization of the South Korean Norovirus GII-4 variant CUK-3. Virology Journal (Virol J), 8, 167-171. doi: 10.1186/1743-422X-8-167
• Wang, J., Liu, B., Wang, N., Lee, Y., Liu, C., Li, K., (2011). TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection. Journal of Virology (J Virol), 85:8, 3733-3745. doi: 10.1128/JVI.02546-10
• Yun, S., Kim, J., Song, B., Jeong, A., Jee, Y., Lee, C., Paik, S., Koo, Y., Jeon, I., Byun, S., Lee, Y., (2010). Complete genome sequence and phylogenetic analysis of a recombinant Korean norovirus, CBNU1, recovered from a 2006 outbreak. Virus Research (Virus Res), 152:1-2, 137-152. doi: 10.1016/j.virusres.2010.06.018
• Jang, S., Jeong, W., Kim, M., Lee, Y., Lee, J., Lee, G., Paik, S., Koh, G., Kim, J., Lee, C., (2010). Detection of replicating negative-sense RNAs in CaCo-2 cells infected with human astrovirus. Archives of Virology (Arch Virol), 155:9, 1383-1389. doi: 10.1007/s00705-010-0718-9
• Yi, H., Kim, M., Jang, S., Lee, Y., Ahn, J., Lee, C., (2009). Cellular signals involved in cyclooxygenase-2 expression induced by human cytomegalovirus. Virus Research (Virus Res), 146:1-2, 89-96. doi: 10.1016/j.virusres.2009.09.004
• Yun, S., Song, B., Koo, Y., Jeon, I., Byun, S., Park, J., Joo, Y., Kim, S., Lee, Y., (2009). Japanese encephalitis virus-based replicon RNAs/particles as an expression system for HIV-1 Pr55Gag that is capable of producing virus-like particles. Virus Research (Virus Res), 144:1-2, 298-305. doi: 10.1016/j.virusres.2009.04.014
• Yun, S., Choi, Y., Song, B., Lee, Y., (2009). 3’ cis-acting elements that contribute to the competence and efficiency of Japanese encephalitis virus genome replication: functional importance of sequence duplications, deletions, and substitutions. Journal of Virology (J Virol), 83:16, 7909-7930. doi: 10.1128/JVI.02541-08
• Song, B., Yun, S., Choi, Y., Kim, J., Lee, C., Lee, Y., (2008). A complex RNA motif defined by three discontinuous 5-nucleotide-long strands is essential for Flavivirus RNA replication. RNA-A Publication of the RNA Society (RNA), 14:9, 1791-1813. doi: 10.1261/rna.993608
• Kim, J., Yun, S., Song, B., Hahn, Y., Lee, C., Oh, H., Lee, Y., (2008). A single N-linked glycosylation site in the Japanese encephalitis virus prM protein is critical for cell type-specific prM protein biogenesis, virus particle release, and pathogenicity in mice. Journal of Virology (J Virol), 82:16, 7846-7862. doi: 10.1128/JVI.00789-08
• Yun, S., Choi, Y., Yu, X., Song, J., Shin, Y., Ju, Y., Kim, S., Lee, Y., (2007). Engineering the Japanese encephalitis virus RNA genome for the expression of foreign genes of various sizes: implications for packaging capacity and RNA replication efficiency. Journal of Neurovirology (J Neurovirol), 13:6, 522-535. doi: 10.1080/13550280701684651
• Lee, E., Song, M., Shin, J., Lee, Y., Kim, C., Lee, Y., Kim, H., Choi, Y., (2007). Genetic characterization of avian metapneumovirus subtype C isolated from pheasants in a live bird market. Virus Research (Virus Res), 128:1-2, 18-25. doi: 10.1016/j.virusres.2007.03.029
• Yin Ji, X., Kang, M., Choi, J., Jeon, H., Han, H., Kim, J., Son, B., Lee, Y., Hahn, Y., (2007). Levels of intra- and extracellular heat shock protein 60 in Kawasaki disease patients treated with intravenous immunoglobulin. Clinical Immunology (Clin Immunol), 124:3, 304-310. doi: 10.1016/j.clim.2007.05.006
• Lee, Y., Shin, J., Song, M., Lee, Y., Choi, J., Lee, E., Jeong, O., Sung, H., Kim, J., Kwon, Y., Kwon, J., Kim, C., Webby, R.J, Webster, R.G, Choi, Y., (2007). Continuing evolution of H9 influenza viruses in Korean poultry. Virology, 359:2, 313-323. doi: 10.1016/j.virol.2006.09.025
• Shin, J., Song, M., Lee, E., Lee, Y., Kim, S., Kim, H., Choi, J., Kim, C., Webby, R.J, Choi, Y., (2006). Isolation and characterization of novel H3N1 swine influenza viruses from pigs with respiratory diseases in Korea. Journal of Clinical Microbiology (J Clin Microbiol), 44:11, 3923-3927. doi: 10.1128/JCM.00904-06
• Choi, Y., Yun, S., Kang, S., Lee, Y., (2006). Identification of 5' and 3' cis-acting elements of the porcine reproductive and respiratory syndrome virus: acquisition of novel 5' AU-rich sequences restored replication of a 5'-proximal 7-nucleotide deletion mutant. Journal of Virology (J Virol), 80:2, 723-736. doi: 10.1128/JVI.80.2.723–736.2006
• Lee, Y., Tscherne, D.M, Yun, S., Frolov, I., Rice, C.M, (2005). Dual mechanisms of pestiviral superinfection exclusion at entry and RNA replication. Journal of Virology (J Virol), 79:6, 3231-3242. doi: 10.1128/JVI.79.6.3231–3242.2005
• Kang, S., Yun, S., Park, H., Park, C., Choi, H., Lee, Y., (2004). Molecular characterization of PL97-1, the first Korean isolate of the porcine reproductive and respiratory syndrome virus. Virus Research (Virus Res), 104:2, 165-179. doi: 10.1016/j.virusres.2004.04.003
• Yun, S., Kim, S., Choi, W., Nam, J., Ju, Y., Park, K., Cho, H., Lee, Y., (2003). Molecular characterization of the full-length genome of the Japanese encephalitis viral strain K87P39. Virus Research (Virus Res), 96:1-2, 129-140. doi: 10.1016/S0168-1702(03)00181-3
• Yun, S., Kim, S., Rice, C.M, Lee, Y., (2003). Development and application of a reverse genetics system for Japanese encephalitis virus. Journal of Virology (J Virol), 77:11, 6450-6465. doi: 10.1128/JVI.77.11.6450–6465.2003
• Kim, S., Woo, C., Lee, Y., Son, B., Kim, J., Chae, H., Youn, S., Park, S., (2001). Genotyping CagA, VacA subtype, IceA1, and BabA of Helicobacter pylori isolates from Korean patients, and their association with gastroduodenal diseases. Journal of Korean Medical Science (J Korean Med Sci), 16:5, 579-584. doi: 10.3346/jkms.2001.16.5.579
• Lee, Y., Liu, B., Yu, X., (1999). Formation of virus assembly intermediate complexes in the cytoplasm by wild-type and assembly-defective mutant human immunodeficiency virus type 1 and their association with membranes. Journal of Virology (J Virol), 73:7, 5654-5662.
• Lee, Y., Tian, C., Yu, X., (1998). A bipartite membrane-binding signal in the human immunodeficiency virus type 1 matrix protein is required for the proteolytic processing of Gag precursors in a cell type-dependent manner. Journal of Virology (J Virol), 72:11, 9061-9068.
• Lee, Y., Yu, X., (1998). Identification and characterization of virus assembly intermediate complexes in HIV-1-infected CD4+ T cells. Virology (Virology), 243:1, 78-93.
• Lee, Y., Tang, X., Cimakasky, L.M, Hildreth, J.E, Yu, X., (1997). Mutations in the matrix protein of human immunodeficiency virus type 1 inhibit surface expression and virion incorporation of viral envelope glycoproteins in CD4+ T lymphocytes. Journal of Virology (J Virol), 71:2, 1443-1452.

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Other

Magazine/Trade Publications

• Lee, Y., (2020). What is the hepatitis C virus? : The Nobel Prize. Donga Science *

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.