Ying Liu
Animal, Dairy, & Veterinary Sciences (ADVS)
Research Assistant Professor
Educational Background
Biography
PhD in Animal Reproductive Biology, Aarhus University (Denmark), 2011. Postdoc training, Reproductive Toxicology, Aarhus University (Denmark).
Research Interests
The area of her research interest includes: Animal reproductive science, embryology, reproductive biology techniques in research, somatic cell nuclear transfer; Cryopreservation of oocytes and embryos; In-vitro induce reprogramming of somatic cells; Epigenetic modification in embryos; Animal models for human diseases (pigs, sheep and goats), and animal models for reprotoxic research (mice)
Publications | Abstracts
- Perisse, I.V, Fan, Z., Liu, Y., Vaghela, N., Patrick, T., Regouski, M., Van Wettere, A., Leir, S., Harris, A., White, K.L, Polejaeva, I., (2024). Towards Genetic Correction of Meconium Ileus by Intestinal Expression of CFTR in CFTR-null Sheep Model. Cystic Fibrosis Foundation 2024 Research Conference
- Regouski, M., Liu, Y., Rutigliano, H., Polejaeva, I., (2023). MP-453085-7 PROGESTERONE WITHDRAWAL ASSOCIATED WITH INCREASED ATRIAL FIBRILLATION SUSCEPTIBILITY IN FEMALES. Heart Rhythm
- Adams, L., Liu, Y., B. Durrant, B., Young, C., E. Ruggeri , E., R. Krisher, R., Patrick, T., Polejaeva, I., (2023). Quantification of mitochondrial DNA copy number in interspecies somatic cell nuclear transfer embryos. Reproduction, Fertility and Development
- Blocher, R., Liu, Y., Adams, L., Polejaeva, I., (2023). Evaluation of mitochondrial quantity and distribution in bovine oocytes matured in cytokine-supplemented medium. Reproduction, Fertility and Development
- Kuczynski,, C., Perisse, ., Regouski, M., Alipour, E., LaPradd, C., Liu, Y., Beaty, M., Kim-Shapiro, D., Atala, A., Polejaeva, I., Porada, C., Almeida-Porada, M., (2022). Novel Sheep Model of Sickle Cell Disease Reproduces Human Clinical and Laboratory Parameters. Blood
- Su, Y., Wang, L., Fan, Z., Liu, Y., Zhu, J., Kaback, D., Oudiz, J., Patrick, T., Yee, S., Tian, X., Polejaeva, I., Tang, Y., (2021). Establishment of bovine induced pluripotent stem cells. Reproduction, fertility, and development
- Adams, L., Liu, Y., Durrant, B., Ruggeri, E., Young, C., Polejaeva, I., (2021). Use of a hand-made cloning protocol to reduce oocyte mitochondria. Reproduction, Fertility and Development
- Keim, J., Liu, Y., Regousk, M., Stott, R.D, Singina, G.N, Polejaeva, I., (2021). Effect of cytokine-supplemented maturation medium on bovine somatic cell nuclear transfer embryo development. Reproduction, Fertility and Development
- Keim, J., Zhang, W., Liu, Y., Rutigliano, H., Zhou, A., Polejaeva, I., (2020). Analyzing metabolomic profile of bovine IVF and somatic cell nuclear transfer embryos through Raman spectroscopy. Reproduction, Fertility and Development
- Fan, Z., Regouski, M., Liu, Y., Keim, J., Perisse, I., Oatley, J., Polejaeva, I., (2020). Generation of NANOS2 knockout goats using CRISPR/Cas9 and somatic cell nuclear transfer techniques. Reproduction, Fertility and Development
- Keim, J., Liu, Y., Polejaeva, I., (2019). Increasing in vitro embryonic development through improved oocyte maturation in cattle oocytes. Reproduction, Fertility and Development
- Perisse, I.V, Fan, Z., Liu, Y., Regouski, M., Van Wettere, A., Wang, Z., Harris, A., White, K.L, Polejaeva, I., (2019). Towards the correction of meconium ileus with cystic fibrosis transmembrane conductance regulator (CFTR) intestinal expression in CFTR knockout sheep. Reproduction, Fertility and Development
- Callesen, H., Liu, Y., Pedersen, H., Sorensen, CB, C.B, Bentzon, J., (2018). Production of Genetically Modified Founder Pigs as Models for Human Diseases. Reproduction, Fertility and Development
- Liu, Y., Pedersen, H., Foldager, L., Callesen, H., Sorensen, MT, , (2017). IN VITRO FERTILIZATION IN MOUSE AS A REPROTOXICITY MODEL FOR XENOBIOTICS. Reproduction, Fertility and Development
An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.
Publications | Journal Articles
Academic Journal
- Leir, S., Tkachenko, S., Paranjapye, ., Meckler, F., Van Wettere, A., Kerschner, J.L, Kuznetsov, E., Schacht, M., Gillurkar, ., Regouski, M., Perisse, I.V, Marriott, C.M, Liu, Y., Bunderson, I., White, K.L, Polejaeva, I., Harris, A., (2024). Stellate cells are in utero markers of pancreatic disease in cystic fibrosis.. Molecular Medicine, 30, 115.
- Liu, Y., Stott, R.D, Regouski, M., Fan, Z., Perisse, I.V, Patrick, T., Keim, J., Meng, Q., Polejaeva, I., (2024). A retrospective analysis of sheep generated by somatic cell nuclear transfer.. Theriogenology, 227, 102-111. doi: 10.1016/j.theriogenology.2024.07.017
- Keim, J., Liu, Y., Regouski, M., Stott, R.D, Singina, G.N, White, K.L, Polejaeva, I., (2023). Cytokine supplemented maturation medium improved development to term following somatic cell nuclear transfer (SCNT) in cattle. Reproduction, Fertility and Development, 35, 575-588.
- Ofosu, J., Zhang, Y., Liu, Y., Sun, X., Quan, G., Rodriguez, M.A, Zhou, G., (2023). Cryopreservation of mammalian gametes and embryos: implications of oxidative and nitrosative stress and potential role of antioxidants. Frontiers in Veterinary Science, 10, 1174756.
- Van Wettere, A., Leir, S.H, Cotton, C.U, Regouski, M., Perisse, I.V, Kerschner, J.L, Paranjapye, A., Fan, Z., Liu, Y., Schacht, M., White, K.L, Polejaeva, I., Harris, A., (2023). Early developmental phenotypes in the cystic fibrosis sheep model.. FASEB bioAdvances, 5:1, 13-26.
- Davies, C.J, Fan, Z., Morgado, .P, Liu, Y., Regouski, M., Meng, Q., Thomas, A.J, Yun, S., Byung-Hak, B., Frank, J.C, Perisse, I.V, Van Wettere, A., Lee, Y., Polejaeva, I., (2022). Development and characterization of type I interferon receptor knockout sheep: A model for viral immunology and reproductive signaling. Frontiers in Genetics, 13, 986316. doi: 10.3389/fgene.2022.986316
- Adams, L., Liu, Y., Durrant, B., Ruggeri, E., Young, C., Krisher, R., Polejaeva , i., (2022). Use of Bisection to Reduce Mitochondrial DNA in the Bovine Oocyte. Journal of visualized experiments: JoVE185, doi: 10.3791/64060
- Su, Y., Wang, L., Fan, Z., Liu, Y., Zhu, J., Kaback, D., Oudiz, J., Patrick, T., Yee, S.P, Tian, X.C, Polejaeva, I., Tang, Y., (2021). Establishment of Bovine-Induced Pluripotent Stem Cells. International journal of molecular sciences, 22:19, 10489.
- Perisse, I.V, Fan, Z., Van Wettere, A., Liu, Y., Leir, S., Keim, J., Regouski, M., Wilson, M.D, Cholewa, K.M, Mansbach, S.N, Kelley, T.J, Wang, Z., Harris, A., White, K.L, Polejaeva, I., (2021). Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics. FASEB BioAdvances, 3:10, 841.
- Wu, C., Dai, J., Zhang, S., Sun, L., Liu, Y., Zhang, D., (2021). Effect of thawing rates and antioxidants on semen cryopreservation in Hu sheep. Biopreservation and Biobanking, 19, 204-209.
- Ciccarelli, M., Giassetti, M.I, Miao, D., Oatley, M.J, Robbins, C., Lopez-Biladeau, B., Waqas, M.S, Tibary, A., Whitelaw, B., Lillico, S., Park, C., Park, K., Telugu, B., Fan, Z., Liu, Y., Regouski, M., Polejaeva, I., Oatley, J.M, (2020). Donor-derived spermatogenesis following stem cell transplantation in sterile NANOS2 knockout males. Proceedings of the National Academy of Sciences, 117:39, 24195--24204.
- Wu, C., Zhang, D., Zhang, S., Sun, L., Liu, Y., Dai, J., (2020). Effect of Rhodiola sachalinensis Aqueous Extract on In Vitro Maturation of Porcine Oocytes and Subsequent In Vitro Embryonic Development. Cellular Reprogramming, 22:6, 277--281.
- Pedersen, H.S, Liu, Y., Foldager, L., Callesen, H., Larsen, K., Sorensen, , M.T, (2019). Calibration of sperm concentration for in vitro fertilization in a mouse reprotoxicity model. Toxicology in Vitro, 55, 58--61.
- Liu, Y., Pedersen, H.S, Larsen, K., Kristensen, Kaja Kj\aer, , Foldager, L., Callesen, H., S\orensen, Martin Tang, , (2019). Combined in vitro fertilization and culture (IVF/IVC) in mouse for reprotoxicity assessment of xenobiotic exposure. Reproductive Toxicology, 89, 115--123.
- Dorado, B., Pløen, G.G, Barettino, A., Macias, A., Gonzalo, P., Andres-Manzano, , M., Gonz\'alez-G\'omez, , C., Gal\'an-Arriola, , C., Alfonso, , J., Lobo, M., López-Martín, G.J, Molina, A., Sánchez-Sánchez, R., Gadea, J., Sánchez-González, J., Liu, Y., Callesen, H., Filgueiras-Rama, D., Sørensen, C.B, Andrés, V., (2019). Generation and characterization of a novel knockin minipig model of Hutchinson-Gilford progeria syndrome. Cell discovery, 5:1, 1--15.
- Wu, C., Zhang, D., Zhang, S., Sun, L., Liu, Y., Dai, J., (2019). Optimizing treatment of DNA methyltransferase inhibitor RG108 on porcine fibroblasts for somatic cell nuclear transfer. Reproduction in Domestic Animals, 54:12, 1604--1611.
- Liu, C., Liu, Y., Larsen, K., Hou, Y., Callesen, H., (2018). Calcium-sensing receptor (CASR) is involved in porcine in vitro fertilisation and early embryo development. Reproduction, Fertility and Development, 30:2, 391--398.
- Li, R., Liu, Y., Pedersen, H.S, Callesen, H., (2018). Effect of cumulus cells and sperm concentration on fertilization and development of pig oocytes. Reproduction in Domestic Animals, 53:4, 1009--1012.
- Callesen, M.M, Arnadottir, Sigrid S, , Lyskjaer, Iben, , Orntoft, MaiBritt W, , Hoyer, Soren, , Dagnaes-Hansen, Frederik, , Liu, Y., Li, R., Callesen, H., Rasmussen, M.H, Berthelsen, M.F, Thomsen, M.K, Schweiger, P.J, Jensen, K.B, Andersen, C.L, (2017). A genetically inducible porcine model of intestinal cancer. Molecular oncology, 11:11, 1616--1629.
- Li, R., Liu, Y., Pedersen, H.S, Callesen, H., (2017). Cytoplasmic membrane activities during first cleavage of zona-free porcine embryos: description and consequences. Reproduction, Fertility and Development, 29:3, 557--564.
- Liu, Y., Lucas-Hahn, A., Petersen, B., Li, R., Hermann, D., Hassel, P., Ziegler, M., Larsen, K., Niemann, H., Callesen, H., (2017). Developmental competence and epigenetic profile of porcine embryos produced by two different cloning methods. Cellular Reprogramming, 19:3, 171--179.
- Secher, J.O, Liu, Y., Petkov, S., Luo, Y., Li, D., Hall, V.J, Schmidt, M., Callesen, H., Bentzon, J.F, Sorensen, Charlotte B, , Freude, .K, Hyttel, P., (2017). Evaluation of porcine stem cell competence for somatic cell nuclear transfer and production of cloned animals. Animal reproduction science, 178, 40--49.
- Berthelsen, M.F, Callesen, M.M, Ostergaard, Tanja S, , Liu, Y., Li, R., Callesen, H., Dagnaes-Hansen, Frederik, , Hamilton-Dutoit, S., Jakobsen, J.E, Thomsen, M.K, (2017). Pancreas specific expression of oncogenes in a porcine model. Transgenic Research, 26:5, 603--612.
- Staunstrup, N.H, Stenderup, K., Mortensen, S., Primo, M.N, Rosada, C., Steiniche, T., Liu, Y., Li, R., Schmidt, M., Purup, S., Dagnæs-Hansen, F., (2017). Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins alpha2 and beta1. Disease Models \& Mechanisms, 10:7, 869--880.
- Li, J., Li, R., Villemoes, K., Liu, Y., Purup, S., Callesen, H., (2015). Developmental potential and kinetics of pig embryos with different cytoplasmic volume. Zygote, 23:2, 277--287.
- Liu, Y., Li, J., Lovendahl, Peter, , Schmidt, M., Larsen, K., Callesen, H., (2015). In vitro manipulation techniques of porcine embryos: a meta-analysis related to transfers, pregnancies and piglets. Reproduction, Fertility and Development, 27:3, 429--439.
- Pedersen, H., Liu, Y., Li, R., Purup, S., Lovendahl, P, , Holm, P., Hyttel, P., Callesen, H., (2015). Selection of pre-versus postpubertal pig oocytes for parthenogenetic activation and somatic cell nuclear transfer. Reproduction, Fertility and Development, 27:3, 544--550.
- Li, J., Pedersen, H.S, Li, R., Adamsen, J., Liu, Y., Schmidt, M., Purup, S., Callesen, H., (2014). Developmental potential of pig embryos reconstructed by use of sow versus pre-pubertal gilt oocytes after somatic cell nuclear transfer. Zygote, 22:3, 356--365.
- Li, R., Pedersen, K.S, Liu, Y., Pedersen, H.S, Laegdsmand, Mette, , Rickelt, L.F, Kuhl, Michael, , Callesen, H., (2014). Effect of red light on the development and quality of mammalian embryos. Journal of assisted reproduction and genetics, 31:7, 795--801.
- Callesen, H., Liu, Y., Pedersen, H.S, Li, R., Schmidt, M., (2014). Increasing efficiency in production of cloned piglets. Cellular Reprogramming (Formerly" Cloning and Stem Cells"), 16:6, 407--410.
- Liu, Y., Ostrup, Olga, , Li, R., Li, J., Vajta, Gabor, , Kragh, P.M, Schmidt, M., Purup, S., Hyttel, P., Klaerke, Dan, , Callesen, H., (2014). Long-term effect on in vitro cloning efficiency after treatment of somatic cells with Xenopus egg extract in the pig. Reproduction, Fertility and Development, 26:7, 1017--1031.
- Zhou, G., Zeng, Y., Meng, Q., Liu, Y., Dai, Y., Zhu, S., Bunch, T.D, Hou, Y., (2013). Decreased expression of CD9 in bovine oocytes after cryopreservation and the relationship to fertilization capacity. Molecular reproduction and development, 80:6, 451--459.
- Li, R., Liu, Y., Pedersen, H.S, Kragh, P.M, Callesen, H., (2013). Development and quality of porcine parthenogenetically activated embryos after removal of zona pellucida. Theriogenology, 80:1, 58--64.
- Liu, Y., Ostrup, O., Li, J., Vajta, G., Lin, L., Kragh, P.M, Purup, S., Hyttel, P., Callesen, H., (2012). Increased blastocyst formation of cloned porcine embryos produced with donor cells pre-treated with Xenopus egg extract and/or digitonin. Zygote, 20:1, 61--66.
- Liu, Y., Ostrup, Olga, , Li, J., Vajta, Gabor, , Kragh, P.M, Purup, S., Callesen, H., (2011). Cell colony formation induced by Xenopus egg extract as a marker for improvement of cloned blastocyst formation in the pig. Cellular Reprogramming (Formerly" Cloning and Stem Cells"), 13:6, 521--526.
- Schmidt, M., Kragh, P.M, Li, J., Du, Y., Lin, L., Liu, Y., Bogh, Ingrid Bruck, , Winther, K., Vajta, G., Callesen, H., (2010). Pregnancies and piglets from large white sow recipients after two transfer methods of cloned and transgenic embryos of different pig breeds. Theriogenology, 74:7, 1233--1240.
- Sun, G., Li, R., Dai, Y., Wang, H., Wang, L., Liu, Y., Ding, F., Wei, H., Li, N., (2009). Apoptosis of transgenic cloned and recloned bovine blastocysts. Progress in Natural Science, 19:7, 821--826.
- Lin, L., Du, Y., Liu, Y., Kragh, P.M, Li, J., Purup, S., Kuwayama, M., Zhang, X., Yang, H., Bolund, L., Vajta, G., (2009). Elevated NaCl concentration improves cryotolerance and developmental competence of porcine oocytes. Reproductive biomedicine online, 18:3, 360--366.
- Zhou, G., Liu, G., Meng, Q., Liu, Y., Hou, Y., Wang, X., Li, N., Zhu, S., (2009). Tetraspanin CD9 in bovine oocytes and its role in fertilization. Journal of Reproduction and Development, 55:3, 305--308.
- Liu, Y., Du, Y., Lin, L., Li, J., Kragh, P.M, Kuwayama, M., Bolund, L., Yang, H., Vajta, G., (2008). Comparison of efficiency of open pulled straw (OPS) and Cryotop vitrification for cryopreservation of in vitro matured pig oocytes. CryoLetters, 29:4, 315--320.
- Hou, Y., Dai, Y., Zhu, S., Zhu, H., Wu, T., Gong, G., Wang, H., Wang, L., Liu, Y., Li, R., (2005). Bovine oocytes vitrified by the open pulled straw method and used for somatic cell cloning supported development to term. Theriogenology, 64:6, 1381--1391.
An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.
Publications | Other
Other
An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.