Zhongde Wang

Animal, Dairy and Veterinary Sciences (ADVS)

Professor


Zhongde Wang

Contact Information

Office Location: Bioinnovations Building 305K
Phone: 435-797-9668
Email: zonda.wang@usu.edu

Educational Background

Nuclear reprogramming by somatic cell nuclear transfer, (Embryonic stem cells and genetic engineering), Massachusetts Institute of Technology, 2004
PhD, Molecular and Cellular Biology, University of Massachusetts at Amherst, 2000
Towards the isolation of esterase and amidase catalytic antibodies: Examination of germinal center diversity by cloning and sequence analysis of genes encoding monoclonal antibodies elicited by a transition state analogue

Biography

Dr. Zhongde Wang is a professor in the Department of Animal, Dairy and Veterinary Sciences at Utah State University. Dr. Wang received his Ph.D. degree in Molecular and Cellular Biology from University of Massachusetts at Amherst and did his postdoctoral training at the Whitehead Institute/Massachusetts Institute of Technology.

Teaching Interests

Metabolic syndromes, Genome engineering, Biotechnology, and Stem cells

Research Interests

Dr. Wang’s research team employs modern genome engineering (GE) techniques, such as CRISPR/Cas9 and transposons, and assisted reproduction technologies (ARTs), such as OPU, IVF, PN injection, ICSI, and SCNT, etc., to 1) create GE animal models of human diseases, 2) improve livestock disease resistance and production performance, and 3) livestock as bioreactors for human therapeutics.

The Wang laboratory is the first to succeed in developing GE techniques in the golden Syrian hamster and has produced a long list (>40) of genetic engineered hamster models, all of which are the first in the world. His laboratory has also recently succeeded in establishing GE techniques in the Hartley guinea pig, Peromyscus sonoriensis, and P. leucopus, and produced multiple GE models in each of these species. Current projects in Wang’s laboratory include conducting GE in the golden Syrian hamster, Hartley guinea pig, Peromyscus sonoriensis, P. leucopus, P. californicus, P. polionotus, naked mole rat and cotton rat to create novel non-murine animal models of human disease. Other non-murine model species are being added to the list of investigation.

His laboratory is also actively engaged in research activities in developing GE chickens, sheep, cattle, and alpacas either using them as bioreactors for therapeutic antibody productions or for improving animal disease resistance and production performance. The Wang laboratory is also conducting research in establishing and characterizing authentic embryonic stem (ES) cells and induced pluripotent stem (iPS) cells in each of the non-murine rodent species and farm animals that his laboratory is working with. We define authentic ES and iPS cells as those that, when injected into or aggregated with host embryos, can not only lead to the production of chimeric animals but also transmit to the germline.

The Wang laboratory is always looking for highly motivated, ambitious, creative, and hardworking individuals to join the lab for postdoctoral and MS/PhD trainings. If you think you have these qualities, please contact Dr. Wang directly at zonda.wang@usu.edu

Awards

CAAS Faculty Researcher of the Year, 2017

ADVS Faculty Researcher of the Year Award, 2017

Lalor Foundation Postdoctoral Fellowships , 2003

Lalor Foundation

Lalor Foundation Postdoctoral Fellowships , 2002

Lalor Foundation


Publications | Abstracts

  • Perisse, I.V, Fan, Z., Liu, Y., Regouski, M., Van Wettere, A., Wang, Z., Harris, A., White, K.L, Polejaeva, I., (2019). Towards the correction of meconium ileus with cystic fibrosis transmembrane conductance regulator (CFTR) intestinal expression in CFTR knockout sheep. Reproduction, Fertility and Development
  • Polejaeva, I., Ranjan, R., Wang, Z., Olsen, A.L, Davies, C., White, K.L, (2014). Transgenic goat models to study cardiac fibrosis and atrial fibrillation. Transgenic research
  • Hu, S., Wang, Z., Polejaeva, I., (2014). Knockout of goat nucleoporin 155 (NUP155) gene using CRISPR/CAS9 systems.. Reproduction, Fertility and Development
  • Polejaeva, I., Ranjan, R., Hall, J., Rutigliano, H., Thomas, A.J, Dosdall, D., MacLeod, R., Marrouche, N., Wang, Z., Olsen, A.L, White, K.L, Davies, C., (2013). Cardiac specific overexpression of Transforming Growth Factor Beta1 (TGF-Beta1) increases susceptibility to atrial fibrillation in transgenic goats. Circulation
  • Lee, S.R, Park, H., Kong, I., Wang, Z., (2013). A transcription activator-like effector nuclease (talen)-mediated universal gene knock-in strategy for mammary glands-specific expression of recombinant proteins in dairy cattle. Reprod Fertil Dev
  • Fan, Z., Lee, S.R, Park, H., Lucibello, K., Meng, Q., Sessions, B.R, White, K.L, Bunch, T.D, Wang, Z., (2013). Genetic inactivation of the Sry gene in Argali wild and Romney domestic sheep with CRISPR/Cas systems for producing sex-reversed female animals. Reproduction, Fertility and Development
  • Hu, S., Wang, Z., Polejaeva, I., (2013). KNOCKOUT OF GOAT NUCLEOPORIN 155 (NUP155) GENE USING CRISPR/Cas9 SYSTEMS. Reprod Fertil Dev
  • Meng, Q., Hall, J., Rutigliano, H., Zhou, X., Sessions, B.R, Stott, R.D, Panter, K., Davies, C., Ranjan, R., Dosdall, D., MacLeod, R., Marrouche, N., White, K.L, Wang, Z., Polejaeva, I., (2012). Generation of cloned transgenic goats with cardiac specific overexpression of transforming growth factor β1. Reproduction, Fertility & Develpment
  • Polejaeva, I., Hall, J., Meng, Q., Zhou, X., Sessions, B.R, Panter, K., Stott, R.D, Rutigliano, H.M, Davies, C., Wang, Z., Ranjan, R., Dosdall, D., MacLeod, R., Marouche, N., White, K.L, (2012). Development of a transgenic goat model with cardiac-specific overexpression of human transforming growth factor-β1 to study the relationship between atrial fibrosis and atrial fibrillation. Circulation Research
  • Jackson, L., Barnett, S., Wang, Z., Rishid, K., Growth and protein production of a recombinant CHO cell line utilizing a novel antibody-free Fetal Bovine Serum. International Society for BioProcess Technology

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Journal Articles

Academic Journal

Professional Journal

  • Gilliland, T., Liu, Y., Li , R., Dunn, M., Cottle, E., Terada, Y., Ryckman, Z., Alcorn, M., Vasilatos, S., Lundy, J., Larson, D., Wu, H., Luke, T., Bausch, C., Egland, K., Sullivan, E., Wang, Z., Klimstra, W.B, (2021). Protection of human ACE2 transgenic Syrian hamsters from SARS CoV-2 variants by human polyclonal IgG from hyper-immunized transchromosomic bovines.. bioRxiv : the preprint server for biology

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Publications | Other

Other

  • Wang, Z., (2016). Correction: STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control.. PLoS pathogens
  • Polejaeva, I., Wang, Z., Hu, S., Ranjan, R., Davies, C., Thomas, A., White, K.L, (2015). Method for transgenic bovidae expressing cardiac fibrosis and associated pathology. United States Patent Application Publication *

An asterisk (*) at the end of a publication indicates that it has not been peer-reviewed.

Teaching

ADVS 6060 - Genetics of Metabolic syndromes, Fall 2021

Graduate Students Mentored

julio Landinez Aponte, Animal, Dairy & Vet Sciences
julio Landinez Aponte, Animal, Dairy & Vet Sciences
julio Landinez Aponte, Animal, Dairy & Vet Sciences
Joseph Hawkes, Animal, Dairy & Vet Sciences, September 2017
Nick Robl, Animal, Dairy & Vet Sciences, September 2016
Jinxin Miao, Other, September 2015
Dane Rasmussen, Animal, Dairy & Vet Sciences, September 2013
Jacqueline LaRose, Animal, Dairy & Vet Sciences, September 2012