In Vivo Antiviral Testing

The IAR routinely evaluates antiviral efficacy using in vivo models. We have a large selection of viruses and models available, including BSL-3, BSL-3+, and select agent viruses. The viruses listed below have been well-characterized in each of the specific animals. We have decades of experience evaluating antiviral efficacy, immune responses to viral infection, pharmacokinetic studies, cytokine and biomarkers of viral disease, and maximum tolerated dose studies. Please contact Michelle Mendenhall (michelle.mendenhall@usu.edu) or Dr. Brett Hurst (brett.hurst@usu.edu) for details and pricing. Below is a description of the animal models available for in vivo screening.

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Family Pathogen Host Species Model for Human Disease/Condition Reference
Arenaviridae Pichinde virus hamster and guinea pig arenaviral hemorrhagic fever Mendenhall et al. 2011
Arenaviridae Tacaribe virus mouse arenaviral infection Gowen et al. 2010
Arenaviridae Junin virus guinea pig and mouse Argentine hemorrhagic fever Gowen et al. 2017
Arenaviridae Lymphocytic choriomeningitis virus mouse Old World arenavirus hemorrhagic fever Hickerson et al. 2018
Coronaviridae SARS coronavirus mouse acute respiratory distress syndrome Day et al. 2009
Coronaviridae SARS coronavirus 2 (Mouse-adapted) BALB/c mouse respiratory disease In Progress
Coronaviridae SARS coronavirus 2 human ACE2 mouse (transgenic) respiratory disease, encephalitis In Progress
Coronaviridae SARS coronavirus 2 wild-type hamster respiratory disease In Progress
Coronaviridae SARS coronavirus 2 human ACE2 hamster (transgenic) respiratory disease, encephalitis In Progress
Flaviviridae West Nile virus mouse and hamster encephalitis and paralysis Morrey et al. 2008
Flaviviridae Banzi virus mouse encephalitis Julander et al. 2007
Flaviviridae Dengue virus AG129 mouse dengue fever/dengue hemorrhagic fever Julander, Perry, and Shresta 2011
Flaviviridae Usutu virus AG129 mouse encephalitis In progress
Flaviviridae Yellow fever virus hamster Yellow fever Julander et al. 2014
Flaviviridae Zika virus AG129 mouse encephalitis Julander et al. 2017
Hepadnaviridae Hepatitis B virus mouse hepatitis B in liver and serum Morrey et al. 2009
Orthomyxoviridae Influenza A (H1N1 seasonal) mouse pneumonia Smee et al. 2016
Orthomyxoviridae Influenza A (H1N1 seasonal) oseltamivir-resistant mouse pneumonia Smee et al. 2013
Orthomyxoviridae Influenza A (H1N1 pandemic) mouse pneumonia Smee et al. 2013
Orthomyxoviridae Influenza A (H1N1 pandemic) oseltamivir-resistant mouse pneumonia Smee et al. 2012
Orthomyxoviridae Influenza A (H3N2 seasonal) mouse pneumonia Smee et al. 2016
Orthomyxoviridae Influenza A (H5N1 low pathogenic avian) mouse pneumonia Smee et al. 2010
Orthomyxoviridae Influenza A (H5N1 high pathogenic avian) mouse pneumonia Kumaki et al. 2011
Orthomyxoviridae Influenza A (H7N9) mouse pneumonia Tharakaraman et al. 2015
Orthomyxoviridae Influenza B (Victoria lineage) mouse pneumonia In progress
Orthomyxoviridae Influenza B (Yamagata lineage) mouse pneumonia Warfield et al. 2016
Phenuiviridae Punta Toro mouse and hamster Rift Valley Fever Gowen et al. 2010
Phenuiviridae Rift Valley Fever mouse and hamster Rift Valley Fever Smee et al. 2018
Phenuiviridae Severe fever w/thrombocytopenia syndrome mouse and hamster severe fever with thrombocytopenia syndrome Smee et al. 2016
Phenuiviridae Heartland virus mouse and hamster Heartland virus disease Westover et al. 2017
Picornaviridae Coxsackievirus B3 mouse myocarditis In progress
Picornaviridae Enterovirus D68 AG129 mouse respiratory disease, neurological disease Evans et al. 2018, Hurst et al. 2018
Picornaviridae Enterovirus 71 AG129 mouse neurological disease In progress
Picornaviridae Poliovirus mouse poliomyelitis In progress
Poxviridae Cowpox and vaccinia virus mouse pneumonia with systemic infection Smee et al. 2013
Poxviridae Cowpox and vaccinia virus mouse cutaneous infection Smee et al. 2015
Togaviridae Chikungunya mouse and hamster joint swelling Dagley and Julander, 2013
Togaviridae Eastern equine encephalitis mouse and hamster encephalitis In progress
Togaviridae Semliki Forest mouse encephalitis In progress
Togaviridae Western equine encephalitis mouse encephalitis Julander et al. 2009
Togaviridae Venezuelan equine encephalitis mouse encephalitis Julander et al. 2008